Intracellular Accumulations Flashcards
intracellular accumulations are the
represent the buildup of substances that cells cannot immediately use or eliminate
accumulations happen in
cytoplasm ( in free lysosomes) or in the nucleus
accumulations may be
abnormal substances that the cell has produced or the cell may be storing exogenous materials or products of pathological processes
examples of accumulations
accumulation of beta amloid fragments->progress to skeletal muscle disorder->myositis
accumulations may happen
transiently (short time) or permanently and may be harmless or toxic
sources of accumulations (3)
normal body substances, abnormal endogenous products, exogenous products
normal body substance accumulations
sub produced at faster rate than they can be used or broken down
examples of normal body sub accum
lipids, carbs, proteins, melanin, bilirubin - that are present in abnormally large amounts
abnormal endogenous products usually result of
usually result of genetic disorders that dont allow individual to metabolize naturally occurring sub in body
example of abnormal endogenous product accum
delivery of fatty acids to liver increases due to starvation or diabetes mellitus
can result from genetic disorder
von gierke disease- abnormal endogenous accum
most common form of glycolic metabolism disorder= large amounts of glycogen accumulate in liver and kidney b/c of def. in glucose-6-phosphatase enzyme
tay-sachs-disease- abnormal endogenous accum
leads to abnormal lipid accumulation in brain and other tissue causing motor and mental deterioration beg. at 6 months followed by death btwn 2-5
exogenous products accumulation usually result of
result of environmental agents that cannot be broken down
example of exogenous product accum
coal duse that miners inhale- leads to formation of blue line along margins of gum -
tattoos
