intracellular accumulation

Question 1

inadequate removal of normal endogenous substances is a result of a defect in

Answer 1

defects in packaging and transport.
example: fatty liver

Question 2

accumulation of abnormal endogenous substances is a result of a defect in

Answer 2

folding, packaging, transport or secretion

Question 3

abnormal exogenous substance accumulation is due

Answer 3

to the absence of degrading or transporting mechanisms

Question 4

causes for the accumulation of lipids

Answer 4

Alcohol:
↑ synthesis & ↓breakdown of lipids.
Hypoxia: (–) fatty acid oxidation: ↓ ketone bodies
Starvation: ↑ FA mobilization from peripheral stores.

Question 5

Atherosclerosis: accumulation of cholesterol on

Answer 5

the walls of blood vessels, lead to infarction or occlusion

Question 6

Xanthomas (cholesterol accumulation)

Answer 6

accumulation in the sub-cutaneous tissue

Question 7

cholesterolosis

Answer 7

accumulation in the lamina propria of the gallbladder

Question 8

rounded eosinophilic droplets

Answer 8

accumulation of proteins inside cells

Question 9

Glomerulonephritis

Answer 9

Accumulation of proteins in the renal tubules of the kidneys

Question 10

Russel bodies

Answer 10

Ig accumulation

Question 11

accumulation of cytoskeleton protein inside the cell is called

Answer 11

Mallory body (in liver)

Question 12

anthracosis

Answer 12

accumulation in the lymph nodes. discoloration in the lungs

Question 13

lipofuscins

Answer 13

wear-and-tear pigment (brownish yellow)
seen in old age groups
-indication about free radicals injury
-seen in cardiac myocytes

Question 14

how to differentiate between lipofuscin and hemosiderin

Answer 14

Prussian-blue stain