INTRA-URETHRAL ALPROSTADIL GENERAL Flashcards
In comparison to intracavernosal alprostadil, how does the effectiveness of intraurethral alprostadil (MUSE) generally fare?
In general, intraurethral alprostadil (MUSE) is less effective than intracavernosal alprostadil, with an effectiveness rate of approximately 43% to 65% compared to 70% to 90%.
What has intraurethral alprostadil been combined with to improve treatment response?
Intraurethral alprostadil has been combined with a Vacuum Erectile Device (VED) to improve treatment response.
What patient populations should avoid using intraurethral alprostadil (MUSE)?
Intraurethral alprostadil (MUSE) should be avoided in patients with urethral stricture or urethritis, or if the female partner is pregnant.
How is alprostadil absorbed after intraurethral instillation?
Alprostadil is absorbed quickly through the urethra, into the corpus spongiosum, and then into the corpora cavernosum, with about 80% of each dose absorbed by the urethra and corpus spongiosum in less than 10 minutes.
What is the usual dosage range of intraurethral alprostadil and how much is typically needed in most patients?
The usual dosage range is 125 to 1,000 mcg, with 500 mcg typically needed in most patients.
What is the onset and duration of the effects after intraurethral insertion of alprostadil?
The onset is 5 to 10 minutes, and the duration is 30 to 60 minutes.
What percentage of each dose of intraurethral alprostadil is estimated to be delivered to the corpora cavernosum, and what happens to any drug absorbed into the systemic circulation?
20% of each dose is delivered to the corpora cavernosum. Any drug absorbed into the systemic circulation is rapidly metabolized on the first pass through the lungs.
