INTRA-URETHRAL ALPROSTADIL ADVERSE EFFECTS

Question 1

What are the potential adverse effects associated with urethral administration of alprostadil?

Answer 1

Urethral injuries causing bleeding, stricture, and difficulty voiding
- Urethral pain in 24% to 43% of patients (usually mild and tolerable)
- Vaginal burning, itching, or pain in about 6% of female partners
- Rarely, prolonged painful erections (priapism)
- Rarely, syncope and dizziness (likely due to excessively large doses