Intervertebral Disc: Nucleus Pulposus/ Annulus Fibrosus

Question 1

composition of nucleus pulposus

Answer 1

fibrocartilage

Question 2

what is the water concentration in the lumbar nucleus pulposus at birth and after 30

Answer 2

birth = 88%
30 = 70%

Question 3

consequence of non-aggregated glycosaminoglycans in the lumbar nucleus pulposus

Answer 3

nucleus pulposus will loose water under deformation conditions

Question 4

cell associated with the nucleus pulpous until age 11

Answer 4

notochord cells

Question 5

cell associated with the mature nucleus pulposus

Answer 5

reticulocyte-fibroblast and chondroblast

Question 6

organizational pattern for collagen fibers in the nucleus pulposus

Answer 6

they are irregularly orientated and randomly scattered

Question 7

general tissue location is described as having an abundance of collagen type II fibers

Answer 7

cartilage

Question 8

role of collagen type II fibers based on locations where it is dominant

Answer 8

it appears to be related to tissues having a deformation - reformation ability

Question 9

type of collagen that is dominant in the nucleus pulposus

Answer 9

collagen type II

Question 10

appearance of the cervical annulus fibrosus

Answer 10

horse-shoe with anterior margin thick and the lateral margins tapering to the uncinate processes; the posterior margin is thin

Question 11

compensates for thinness of the posterior part of the cervical annulus fibrosus

Answer 11

posterior longitudinal ligament

Question 12

organization of the lumbar annulus fibrosus

Answer 12

12-14 concentric cylindrical lamellae

Question 13

why is the posterior part of the lumbar annulus fibrosis more susceptible to rupture, herniation, prolapse, or protrusion

Answer 13

posterior margin of each lamellas is thing and the posterior longitudinal ligament is also less developed

Question 14

what is the water concentration in the lumbar annulus fibrosis at birth and after
30 yo

Answer 14

birth = 78%
\+30= 70%

Question 15

organizational pattern for glycosaminoglycans in the lumbar annulus fibrosus

Answer 15

typically have a binding site for hyaluronic acid and are thus aggregated

Question 16

type of collagen that is dominant in the annulus fibrosus

Answer 16

collagen type I

Question 17

organization of collagen fibers in the annulus fibrosus

Answer 17

they are parallel with one another in a single lamellas and angled

Question 18

organization of collagen fibers between lamellae

Answer 18

collagen fibers will be angled in the opposite direction such that a spiral- counter spiral organization is observed

Question 19

average angle of collagen fibers within the annulus fibrosus

Answer 19

average 50-60*

Question 20

the attachment site for collagen fibers within the annulus fibrosus

Answer 20

collagen fibers of the OUTER lamellae will become SHARPEYs fibers and penetrate EPIPHYSEAL RIMS

collagen fibers of the INNER lamellae will attach to the CARTILAGINOUS ENDPLATE

Question 21

origin for cells of the annulus fibrosus

Answer 21

sclerotomites

Question 22

cell type associated with the annulus fibrosus

Answer 22

fibroblast and fibrocyte