Interstitial Lung Disease Flashcards
Which pneumocytes produce Surfactant in the lungs?
Type 2 Pneumocytes
State 4 Obstructive Respiratory Disorders
Asthma
Chronic Bronchitis
Emphysema
Bronchiectasis
State 4 Restrictive Respiratory Disorders
Interstitial Lung Disease - Idiopathic Pulmonary Fibrosis - Sarcoidosis - Pneumoconiosis Chest Wall Neuromuscular Diseases
What is Pulmonary Fibrosis?
Infiltration of alveoli and lung interstitium by mesenchymal cells and increased amounts of ECM and collagen
Pulmonary Fibrosis can be associated with Connective tissue diseases. Give examples of 4
- Rheumatoid Arthritis
- Anonkylosing Spondylitis
- Systemic Sclerosis
- Dermatomyositis
What is the diagnostic test of choice for Pulmonary Fibrosis?
CT scan
How does the value of Transfer Factor change in patients with Pulmonary Fibrosis?
Reduced
Give 6 examples of conditions which commonly cause Upper Zone Fibrosis of the Lung? CHARTS
C - Coal workers pneumoconiosis H - Hypersensitivity pneumonitis / Histiocytosis A - Ankylosing Spondylitis R - Radiation T - Tuberculosis S - Silicosis / Sarcoidosis
Give example(s) of antibiotics which can cause Pulmonary Fibrosis
Nitrofuratoin
Give example(s) of chemotherapy agents which can cause Pulmonary Fibrosis
Bleomycin, Mitomycin, Cyclophosphamide, MTX
Give example(s) of anti-arrhythmic agents which can cause Pulmonary Fibrosis
Amiodarone
Give example(s) of DMARDs which can cause Pulmonary Fibrosis
Gold, SSZ
What may be visualised on CT in patients with Pulmonary Fibrosis?
Ground-glass appearance
Honeycombing
What clinical features in the hands may be associated with Pulmonary Fibrosis?
Clubbing
Hypersensitivity pneumonitis is a what type of Hypersensitivity reaction?
Type III (and Type IV) reaction