interstitial lung disease Flashcards
what is interstitial lung disease also known as
diffuse interstitial lung disease
fibrotic interstitial lung disease
pulmonary fibrosis
pneumoconiosis
how many disease entities are there
more than 180
how are the disease entities characterized
acute
sub-acute
chronic inflammatory infiltration of alveolar walls by cells, fluid, and connective tissue
what happens if left untreated
inflammatory process can progress to irreversible pulmonary fibrosis
what does the ILD group comprise of
wide range of illnesses with varied causes, treatments, and prognoses
do all ILD reflect similar anatomic alterations of lungs and cardiopulmonary manifestations
yes
is ILD restrictive or obstructive
restrictive
anatomic alterations: what happens to the alveoli and pulmonary capillaries
they are destroyed
anatomic alterations: what happens to respiratory bronchioles, alveolar ducts, and alveoli
fibrotic thickening
what other things can form in the lungs
granulomas, honeycombing, cavity formation, fibrocalcific pleural plaques, bronchospasm and excessive bronchial secretions
how should you categorize ILD
group them according to their occupational or environmental exposure, disease associations, and specific pathology
what are occupation/environmental ILD inorganic exposures
asbestosis, coal dust, silica, beryllium, aluminum, barium, clay, iron, certain talcs
what does occupation/environmental iLD organic exposures cause
hypersensitivity pneumonitis
occupation/environmental - therapeutic exposures
antibiotics antiiinflammatory agents cardiovascular agents drug-induced systemic lupus erythematosus irritant gases radiation therapy
what can cause hypersensitivity pneomonitis
moldy hay silage moldy sugar cane mushroom compost barly cheese wood pulp, bark, dust cork dust bird droppings paints
what are the connective tissue disease that are systemic
scleroderma rheumatoid arthritis sjogrens syndrome polymyositis or dermatomyositis systemic lupus sarcoidosis
what are the idiopathic (cause unknown) pulmonary fibrosis
nonspecific cryptogenic organzing pneumonia
lymphocytic interstitial pneumonia
what are the specific pathology ILD
lymphangioleiomyomatosis (LAM)
pulmonary langerhans cell histiocytosis
pulmonary alveolar proteinosis
what are the pulmonary vasculitides
wegeners granulomatois
chrug-strauss syndrom
lymphomatoid granulomatosis
miscellaneous ILD
goodpasture syndrome
idopathic pulmonary hemosiderosis
chronic eosinophilic pneumonia
causes of hypersensitivity pneumonia
typically bacteria that your inhaling while inhaling the moldy organic materia
what gases can cause ILD
chlorine, ammonia, ozone, nitrogen dioxide, phosgene
can chemotherapeutic drugs cause lung disease
yes
can oxygen cause ILD and what else can it lead to
yes, then it causes ARDS then death
