ch 28 guillain-barre syndrome Flashcards
what is guillain-barre
rare disorder of peripheral nervous system in which flaccid paralysis of the skeletal muscles and loss of the reflexes develop in a previously healthy patient
what do the nerves show microscopically
demyelination, inflammation, edema
what happens to the nerve impulses
the transmission decreases leading to paralysis
what happens to the mylan sheath of the peripheral nerves
lymphocytes and macrophages attack and strip off the mylan sheath
what do antibodies titers show in early stage
high serum levels, elevated levels of IgM, anti-PMN antibody
what happens to antibodies during the recovery phase
antibodies reduce rapidly
when does the onset of GB occur
one to four weeks after a febrile episode
what are the early symptoms
fever, malaise, nausea, prostration, tingling sensation and numbness, skeletal paralysis and loss of deep tendon reflexes in feet and lower legs
what are the progressive symptoms
muscle paralysis moves upward to arms, neck, pharyngeal, and facial muscles
what cranial nerves are affected during the progressive stage
cranial nerves IX and X
what happens to the gag reflex during the progressive stage
decreased or absent and dysphagia occurs
non-cardiopulmonary manifestations
progressive paralysis tingling sensation loss of deep tendon reflexes sensory nerve impairment peripheral facial weakness decreased gag reflex
when does paralysis generally peak in amount of days
less than 10 days
what happens after paralysis reaches its maximum
remains unchanged for a few days or weeks
when does recovery generally begin
spontaneously and continues for weeks or in rare cases months
