Internal Medicine Tips Tricks and Techniques Part I Flashcards
What is the mechanism of Digoxin
Inhibits Sodium potassium ATPase
What are some common anti-arrythmic drugs
…
maxalt
rizatriptan
What is the treatment of bells palsy
steroids for anti-inflammatory.
Studies have not shown a decrease in symptoms when steroids are combined with acyclovir (up to date)
What is the SPIKES protocol
- SET up the Interview
- Assess the patients PERCEPTION
- Obtain the patients INVITATION
- Giving KNOWLEDGE and information to the patient
- Address the patients EMOTIONS
What is the antibiotic treatment for Cat Bites
- Monotherapy with a beta-lactam/beta-lactamase inhibitor, such as one of the following:
a) Ampicillin-sulbactam
b) Piperacillin-tazobactam
c) Ticarcillin-clavulanate - A third generation cephalosporin
- Metronidazole 500 mg IV every eight hours
What is the treatment for increased ammonia levels
- Lactulose (45-90grams QD) You want to create 2-3 soft stools per day with a pH less than 6. 2. Oral antibiotic such as Neomycin or rifaxmin
What does QHS mean
At bed time
What does QAC mean
with meals
What does QD
daily
What does QOD mean
every other day
efudex
fluorouracil topical
Lexapro
Escitalopram
Victoza
Liraglutide
What is liraglutide
activates glucagon-like-peptide-1 (GLP-1) receptor, increasing insulin secretion, decreasing glucagon secretion, and delaying gastric emptying (incretin mimetic)
Also helps with weight loss
Glucosamine Sulfate
A dietary supplement not a drug. Used to help prevent joint degeneration
Name the rapid acting insulin
Lispro,
Aspart,
Glulisine,
Onset in 15 - 30 minutes
Regular (30 minutes - 1 hour)
Name the intermediate acting insulin
NPH;
Onset in 1-2 hours
Name the long acting insulin
Glargine (onset in 4-6 hours)
Detemir (onset in 3-4 hours)
Used for basal insulin control
When should a sliding scale insulin be used
In patients with only intermittent minor BG elevations
How often should insulin be measured in patients taking insulin
at least 4 times per day;
Preprandially and at bed time
What is tested for when looking for ketones associated with DKA
b-hydroxybutyrate in the serum;
urine ketones are also often present
What are the big 3 that is used in the treatment of DKA
Fluids
Insulin
Potassium
If a patient has DKA and is hypotensive, how is their fluid load
greater 10% loss of fluids
What are major classes of T2DM
Metformin, insulin secretagogues, DPP IV Inhibitors, GLP mimetics, TZD's,
All are effective with in days to weeks except TZD’s which may take weeks to months
First line treatment for T2DM
BG 200 combination therapy and possibly insulin
What are the insulin secretagogues
SFU's, Non SFU's, Biguanides, a-glucosidase inhibitors, TZD's, DPP-4 Inhibitors, Bile Acid sequesterants, Dopamine receptor agonist, GLP agonist
What is the mechanism of SFU’s
Increase insulin secretion by binding to specific receptors in B cells. Must be taken 30 - 60 minutes before meals to prevent hypoglycemia
What is contraindication for glyburide
Impaired renal function and used with caution in the elderly
Name the non SFU’s
Repaglinide,
Nateglinide
Name the biguanides
metformin
Name the a-glucosidase inhibitors
acarbose
miglitol
Name the thiazolidinediones
Rosiglitazone
Pioglitazone
Name the DPP 4 inhibitors
Sitagliptin
Saxagliptin
Vildagliptin
Name the bile acid sequestrants used in the treatment of T2DM
colesevelam hydrochloride
Name the dopamine agonist used in the treatment of T2DM
Bromocryptine Mesylate
Name the GLP Agonist
Exenatide
Name the amylin analogues
Pramlinitide acetate
What are the common side effects of SFU’s
hypoglycemia and weight gain
What are the common side effects of Non SFU’s
Hypoglycemia and weight gain
less severe than the SFU’s
What are the main adverse side effects of Biguanides
Diarrhea
nausea
abdominal pain or cramping
Lactic acidosis
What are the main adverse side effects of TZD’s
Weight gain, edema
CHF
anemia,
increased fractures in women
What are the main adverse side effects of sitagliptin
Angioedema,
Steven-Johnson syndrome,
URI
What are the main adverse side effects of saxagliptin
urticaria
facial edema
URI
What are the main adverse side effects of bile acid sequestrants
constipation
reduced absorption of some medications
What are the main adverse side effects of dopamine agonist
Nausea asthenia dizziness headache constipation diarrhea
What are the main adverse side effects of GLP agonist
Nausea
vomiting
GI distress
pancreatitis
What are the main adverse side effects of Amylin analogues
Nausea vomiting diarrhea headache hypoglycemia
What is the mechanism of metformin
inhibits hepatic glucose output and stimulates glucose uptake in peripheral tissues
What is the mechanism of a-glucosidase inhibitors
Block polysaccharide and disaccharide breakdown and decrease postprandial hyperglycemia when administered with food.
What are the main adverse effects of the a-glucosidase inhibitors
gas
bloating
diarrhea
abdominal pain
What is the mechanism of the TZD’s
increase insulin sensitivity in muscle, adipose tissue and liver.
When is TZD’s contraindicated
compromised cardiac function NYHA Class 3 and 4
What is the mechanism of DPP 4 inhibitors
Blocks the enzyme that breaks down endogenous GLP, which is an incretin secreted from the intestinal L cells. Increased levels of GLP reduce BG concentration by inhibiting glucagon secretion from the pancreatic alpha cells and by stimulating insulin secretions
What is the mechanism for GLP agonist
peptides are structurally similar to GLP-1 but resist breakdown by DPP enzyme. Have a longer half life than native FLP 1 and reach higher blood and tissue levels
What is the treat of NKHS
- correct the fluid imbalance
- electrolyte replenishment (potassium)
- Gradual correction of hyperglycemia with fluid and insulin
What are some complications of NKHS
Thromboembolic events
cerebral edema
adult respiratory distress syndrome rhabdomyolysis
What is the problem with correcting hyperglycemic episodes too rapidly
osmotic encephalopathy
What is the main purpose of controlling BG in DM
prevention of chronic microvascular insufficiency
- Diabetic Retinopathy
- Diabetic Neuropathy
- Diabetic Nephropathy
Prevention of chronic macro vascular insufficiency
- CHD
- PVD.
Miscellaneous Complications
- Erectile Dysfunction
- Diabetic Foot Ulcers
What is heart failure
A clinical syndrome in which either structural or functional abnormalities in the heart impair its ability to meed the metabolic demands of the body
What are the two classes of heart failure
Systolic dysfunction
Diastolic dysfunction
What are the stages of heart failure
- Asymptomatic
- Mild symptoms (mild SOB/Palpitations with physical activity)
- Marked limitations in activity (walking 20-100 meters)
- Severe limitations (at rest)
What are the classes of heart failure
A. No structural disease/ symptoms. Has risk factors
B. Abnormal LV systolic function
C. Structural heart dz and HF symptoms
D. Refractory heart failure symptoms to max medical management
What are the initial labs for suspected HF
CBC CMP Fasting lipid profile Urinalysis Thyroid function BNP (>400 to rule in <100 to rule out)
What is a concern when using vasodilators with HF patients
patients with a fixed cardiac output (aortic stenosis or HCM or with a predominately diastolic dysfunction)
What is the medical mainstays for HF treatment
Beta blockers
Vasodilators
Diuretics (for volume overload)
Why do ARB’s not cause cough and angioedema.
ACE’s will increase bradykinin while ARB’s will not.
How are ACE inhibitors excreted
through the kidneys… need to titrate the dose for renal insufficiency
How do nitrates reduce cardiac ischemia
decreasing ventricular filling pressures and by directly dilating coronary arteries
How does nitroprusside work
Primarily an arterial vasodilator with less potent vasodilatory properties
What diuretic is useful for patients with a low GFR
Metolazine
Its actions are are at the proximal as well as the distal tubule. It may be used in combination with a loop
What are some common side effects of loops
hyperuricemia hypocalcemia ototoxicity rash vasculitis
Remeron
Mirtazipine
What is primary bilary cirrhosis
autoimmune disease of the liver marked by the slow progressive destruction of the small bile ducts (bile canaliculi) within the liver. When these ducts are damaged, bile builds up in the liver (cholestasis) and over time damages the tissue
Keflex
Cephalexin (1st generation cephalosporin)
Xenical
Orlistat
Inhibits gastric and pancreatic lipases, reducing fat absorption
Actos
Pioglitazone
Flexeril
Cyclobenzaprine
glucotrol
glipizide
Tikosyn
Dofetilide (anti arrhythmic: prolongs action potential during phase III)