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pass medicine immunology > interleukins > Flashcards

interleukins Flashcards

1
Q

main sources of IL-1

A

macrophages

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2
Q

main sources of IL-2

A

Th1 cells

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3
Q

main sources of IL-3

A

activated T helper cells

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4
Q

main sources of IL-4

A

Th2 cells

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5
Q

main sources of IL-5

A

Th2 cells

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6
Q

main sources of IL-6

A

macrophages

Th2 cells

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7
Q

main sources of IL-8

A

macrophages

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8
Q

main sources of IL-10

A

Th2 cells

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9
Q

main sources of IL-12

A

dendritic cells
macrophages
B cells

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10
Q

main soures of tumour necrosis factor a (alpha)

A

macrophages

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11
Q

major sources of interferon y (gamma)

A

Th1 cells

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12
Q

function of IL-1

A

acute inflammation

induces fever

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13
Q

function of IL-2

A

stimulates growth and differentiation of T cell response

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14
Q

function of IL-3

A

stimulates differentiation and proliferation of myeloid progenitor cells

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15
Q

function of IL-4

A

stimulates proliferation and differentiation of B cells

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16
Q

function of IL-5

A

stimulate production of eosinophils

17
Q

function of IL-6

A

stimulates differentiation of B cells

induces fever

18
Q

function of IL-8

A

neutrophil chemotaxis

19
Q

function of IL-10

A

inhibits Th1 cytokine production

also known as human cytokine synthesis inhibitory factor and is an ‘anti-inflammatory’ cytokine

20
Q

function of IL-12

A

activates NK cells and stimulates differentiation of naïve T cells into Th1 cells

21
Q

function of tumour necrosis factor a (alpha)

A

induces fever

neutrophil chemotaxis

22
Q

function of interferon y (gamma)

A

activates macrophages

23
Q

cytokines produced by macrophages

A 
tumour necrosis factor a
IL-1
IL-6
IL-8
IL-12
24
Q

cytokines produced by Th1 cells

A

interferon y

IL-2

25
Q

cytokines produced by activated T helper cells

A

IL-3

26
Q

cytokines produced by Th2 cells

A

IL-4
IL-5
IL-6
IL-10

27
Q

cytokines produced by dendritic cells

A

IL-12

28
Q

cytokines produced by B cells

A

IL-12

pass medicine immunology (6 decks)

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