hypersensitivity reactions

Question 1

mechanism of Type I

Answer 1

anaphylactic

antigen reacts with IgE bound to mast cells

Question 2

mechanism of Type II

Answer 2

cell bound

IgG or IgM binds to antigen on cell surface

Question 3

mechanism of Type III

Answer 3

immune complex

free antigen and antibody (IgG, IgA) combine

Question 4

mechanism of Type IV

Answer 4

delayed hypersensitivity

T-cell mediated

Question 5

anaphylaxis

Answer 5

I

Question 6

atopy (eg asthma, eczema, hayfever)

Answer 6

I

Question 7

autoimmune haemolytic anaemia

Answer 7

II

Question 8

ITP

Answer 8

II

Question 9

Goodpasture’s syndrome

Answer 9

II

Question 10

pernicious anaemia

Answer 10

II

Question 11

acute haemolytic transfusion reactions

Answer 11

II

Question 12

rheumatic fever

Answer 12

II

Question 13

pemphigus vulgaris / bullous pemphigoid

Answer 13

II

Question 14

serum sickness

Answer 14

III

Question 15

systemic lupus erythematosus

Answer 15

III

Question 16

post-streptococcal glomerulonephritis

Answer 16

III

Question 17

extrinsic allergic alveolitis (especially acute phase)

Answer 17

III

Question 18

tuberculosis / tuberculin skin reaction

Answer 18

IV

Question 19

graft versus host disease

Answer 19

IV

Question 20

allergic contact dermatitis

Answer 20

IV

Question 21

scabies

Answer 21

IV

Question 22

extrinsic allergic alveolitis (especially chronic phase)

Answer 22

IV

Question 23

multiple sclerosis

Answer 23

IV

Question 24

Guillain-Barre syndrome

Answer 24

IV

Question 25

Graves’ disease

Answer 25

II (possibly V)

Question 26

Myasthenia gravis

Answer 26

II (possibly V)