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PRP Mock Papers Questions > Interactions > Flashcards

Interactions Flashcards

1
Q

CYP540 inducers

A 
DECREASES THE CONC OF DRUG MET BY CYP450
Carbamazepine
Rifampicin
Alcohol
Phenytoin
Griseofulvin
Phenobarbitone
Sulphonylureas
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2
Q

CYP450 inhibitors

A 
INCREASE THE CONC OF DRUGS MET BY CYP450
Sodium valproate
Isoniazid
Cimetidine
Ketoconazole
Fluconazole
Alcohol AND Grapefruit
Chloramphenicol
Erythromycin
Sulfonamides
.
Ciprofloxacin
Omeprazole
Metronidazole
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3
Q

Dugs metabolised by CYP450

A 
warfarin 
combined pill 
theophylline 
corticosteroids
tricyclic antidepressants 
pethidine
statins
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4
Q

Clopidogrel and statins

A

Clopi and statins are met by CYP450
omeprazole is C/I with clopidogrel
safest is pantoprazole
lansoprazole and rabeprazole are OK

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5
Q

Simvastatin interactions

A

bezafibrate and ciprofibrate - 10 MG OD
amiodarone/amlodipine/ranolazine - 20 MG OD
verapamil/diltiazem - 20 MG OD
elbasvir with grazoprevir - 20 MG OD
bempedoic acid/bempedoic acid with ezetimibe - MAX 20 MG OD or 40 MG OD if severe hypercholesterolaemia with high risk CVD
Erythromycin/clarithromycin/telithromycin - C/I
Itraconazoles - C/I
Ciclosporins - C/I
antivirals - C/I

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6
Q

Atorvastatin interactions

A

Ciclosporins (if unavoidable) - 10 MG OD
elbasvir with grazoprevir - 20 MG OD
letermovir WITHOUT ciclosporin - 20 MG OD
sofosbuvir with velpatasvir and voxilaprevir - 20 MG OD
anion exchange resin for heterozygous familial hypercholesterolemia - 40 MG OD

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7
Q

Drug-induced HypERNatraemia

A 
Diuretics 
sodium bicarbonate
sodium chloride
corticosteroids
anabolic steroids
oestrogens
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8
Q

Drug-induced HypONatraemia

A 
ACEI
Heparin
Diuretics
antidepressants (citalopram, etc...)
antipsychotics
carbamazepine
S+S inc: weakness, fatigue or low energy, headache, N+V, muscle spasm, cramps, confusion, irritability.
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9
Q

drug that lower the seizure treshold

A 
tramadol
Imipenem
4th gen cephalosporin
ciprofloxacin
isoniazid
penicillin
antipsychotics
lithium
MAOI
SSRI
SNRI
TCA
Aminophylline
Theophylline
pseudoephedine
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10
Q

medication causing QT prolongation

A 
Erythromycin
Clritthromycin
Fluconazole
Ketoconazole
Dronedarone
Quinidine
Amiodarone
Flecainide
Methadone
antipsychotics
Citalopram/escitalopram
amitriptylline
domperidone
droperidol
ondansetron/Granisetron
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11
Q

Drug induced hyperkalaemia

A 
Potassium-sparing diuretics 
aldosterone antagonist
b-blockers
ACEI
digoxin
trimethoprim and co-trimaxozole
NSAID
heparin
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12
Q

drug that cause hypokalaemia

A 
Laxatives (excessive use - stool excretion)
Diuretics (renal excretion)
Beta-blockers (high dose - taken up by cells)
Corticosteroids (renal excretion)
Insulin (taken up by cells)
Theophylline (taken up by cells)
Penicillins (high dose - renal excretion)
Verapamil (overdose - taken up by cell)
Gentamicin
Sodium Bicarbonate
Amphotericin
Echinochandin antifungals
Cisplatin
Parecoxib
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13
Q

citalopram and NSAID

A

increased risk of hyponatraemia

increased risk of GI bleeding

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14
Q

drugs that cannot be stopped abruptly

A 
SSRI
MAOI
LAMOTRIGINE (2 weeks) 
Corticosteroids 
Hypnotics and anxiolytics 
morphine/ALL opioids
Buprenorphine 
antipsychotics 
antiparkinson drugs 
mirtazapine
lithium 
venlafaxine (need 4 weeks)
Benzodiazepines
Pregabalin - over 1 week
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15
Q

Atorvastatin C/I

A

ciclosporin - VERY BIG MAX 20 MG
Clarithromycin - AVOID
Amlodipine - theoric, pravastatin, rosuvasttain preferred

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16
Q

Drugs causing hypoMagnesium

A 
PPI 
Ciclosporin 
short bowel syndrome
Zoledronic acid
parathyroid hormone
amphoterin B 
Hydroxyzine Hydrochloride
17
Q

Hypercalcaemia S+S

A

loss of appetite
N+V
Constipation and abdominal pain
need to drink more fluids and urinate more
tiredness, weakness and muscle pain
confusion, disorientation and difficulty thinking
headaches
depression
can be caused by tamoxifen, potentiate digoxin toxicity, thiazide-like diuretic, lithium, Vit A, VIT D and Calcium ca lead to hyperC

18
Q

Lithium interactions

A 
Aminophylline - HypoK + torsades de pointes
Amisulpride - QT prolongation
Amiodarone - QT interval prolongation
Amitriptyline - inc neurotoxicity
Apomorphine - inc QT prolongation
thiazide like diuretics - HyopK, torsade de pointes, inc lithium conc
Steroids - HypoK 
loop diuretic - HypoK (torsade de pointe) and inc lithium conc
ARB - inc conc of lithium 
ACEI - inc conc of lithium
Carbamazepine - inc neurotoxicity risk 
NSAID - inc conc of lithium 
Chlorpromazine - inc QT prolongation
SSRI - QT prolongation 
Clarithromycin/erythromycin - QT prolongation
Diltiazem - risk neurotoxicity 
domperidone - risk QT prolongation
Tetracyclines - inc risk lithium toxicity 
Fluconazole - QT interval prolongation 
mefloquine/quinine - QT prolongation
19
Q

Domperidone

A

Linked with arrhythmias and cardiac pb - max 1 week treatment
X in cardiac and GI pb

PRP Mock Papers Questions (15 decks)

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