Integumentary DLA Flashcards
What is hyperkeratosis?
Thickening of the stratum corneum
What is parakeratosis?
Retention of nuclei in the keratinocytes of the stratum Corneum
What is acanthosis?
Increase in thickness of the stratum spinosum
What is acanthylosis?
Broken bonds between cells of the epidermis leading to separation of these cells from each other
Describe basal cell carcinoma
- UV light
- proliferation of basal stem cells
- Dark nuclei with sparse poorly defined cytoplasm
- Cells at the periphery has a characteristic palisades appearance
- Central cells are more randomly arranged
- Invades the dermis and deeper lying structures
- Does not typically metastasize
What are the predisposing factors of squamous cell carcinoma?
- sunlight (UV)
- industrial carcinogens
- chronic ulcers
- tobacco chewing
- burns
- ionizing radiation
- betel nut chewing
- arsenic exposure
What is most common location of squamous cell carcinoma?
More common in head and neck region (likely due to excessive sunlight exposure)
What is squamous cell carcinoma?
- Malignant tumor of keratinocytes
- exposure to UV with DNA damage (inactivation of P53 gene)
- loss of elderly in nuclear size and shape
- Hyperkeratosis and Parakeratosis
- Common in elderly (above 70 years)
- fair skinned > dark skinned
Describe the histological evaluation of squamous cell carcinoma
Dermis deeply infiltrated by islands and sheets of malignant squamous cells
The islands have undifferentiated cells, resembling basal cells, around the parameter
Islands show squamous differentiation with formation of squamous pearls or swirls
What is malignant melanoma?
- malignant transformation of melanocytes
- causes highest number of skin cancer related deaths in US
- more common in whites, Australia/ South Africa
- etiology- exposure to sunlight (UV) light : types- Acute, intermittent, blistering
- increased number of melanocytes with large atypical morphology- arranged at the dermo-epidermal junction
May invade the dermis- metastases(fatal)
What is melan A?
Immunohistocheemistry marker, a specific antibody that stains malignant melanoma cells
What is albinism?
Genetic (autosomal recessive)
- loss of pigmentation of the skin, hair, and eyes
- Lack of tyrosinase
- types: ocular, oculocutaneous
What are the long term implications of albinism?
- skin cancers
- reduced visual acuity/photophobia (macular hypoplasia)
- social stigma
What is Vitiligo?
- Depigmentation disorder
- auto-immune
- destruction of melanocytes
- types: focal, segmental, generalized
How can vitiligo be treated?
Medical:
-topical steroid therapy
- Psolaren photochemotherapy
- Depigmentation
Surgical:
-Autologous skin graft
- Micropigmentation
- Melanocytes transplants
What is Psoraisis?
A chronic inflammatory and hyper proliferative disorder of the skin
- Clinically manifested as well-circumscribed, erythema toes and itchy plaques covered with slavery scales( knees, elbows, lower back, scalp)
- Epidural turnover averages 8-10 days
Characterized by hyperkeratosis and parakeratosis
What are the predisposing factors of psoriasis?
- genetic background
- inciting background (stress)
Explain the pathogenesis of psoriasis
- Exogenous/endogenous antigens: predisposing factors
- Antigen presentation by APCs: Langerhans cells
- T-lymphocyte-mediated immune response
- Cytokine secretion
- Inflammation & cellular hyperproliferation
- Clinical lesions of psoasis
What is parakeratosis?
Retention of nuclei in the stratum corneum
What causes epidermal removal in psoarisis?
Parakeratosis
- prominent itchy areas with increased skin scaling and peeling
- epidermal hyperplasia- increased rate of proliferation
This leads to shedding of the epidermis constantly, resulting in scales seen as whitish patches
What is Bollous pemphigod?
- damage to hemidesmosomes- separation of epidermis & dermis
- Chronic autoimmune blistering disease: skin & mucous membranes (bulla large fluid filled vesicles)
- Antibodies (IgG) specific to hemidesmosomes bind to basement membrane and stimulate leukocytic infiltration
- Eosinophils releases proteases that degrade hemidesmosomes
- Fluid accumulation-blistering formation
- Characteristic by large blisters that don’t easily rupture
What is Pemphigus vulgaris?
Pemphix(blister/bubble)
- Rare autoimmune disorder affecting epidermis and mucosal epithelium
- Desmosomes- separation of the stratum spinosum keratinocytes one from another
- Antibodies target cadherins and desmoplakins and desmogleins
- Atrophy of the prickle cell layer
- Blister formation: easy to rupture- Nikolsky’s sign, skin shears off easily
What causes ACNE?
Inflammation of a sebaceous gland
- Affects 85-100% of people at some point in life
- Genetic predisposition
- Common in adolescents (prior to onset of puberty- adrenal androgens): in all age groups
- Affects face, back, chest upper arm- areas with increased sebaceous glands
What are wound healing?
Skin damage in motion a sequence of events that repairs the skin to its normal (or near normal) structure and function
2 types:
- epidermal wound healing
- deep wound healing
