Cartilage Flashcards

1
Q

What are hyaline cartilage derived from?

A

Mesenchymal cells

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2
Q

What are the cells within hyaline cartilage?

A

Chondroblasts & Chondrocytes

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3
Q

What are in the extracellular matrix of hyaline cartilage?

A

Type 2 collagen fibers

GAGs- hyalauronic acid and glycoproteins

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4
Q

How does hyaline cartilage grow?

A

Appositional & interstitial growth

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5
Q

How does hyaline cartilage degenerate?

A

Doesn’t really degenerate

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6
Q

Describe the calcification of hyaline cartilage

A

Calcifies- bone formation & aging

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7
Q

What is the function of hyaline cartilage?

A
  • supportive
  • cushioning
  • shock absorber
  • growth plate
  • model for bone formations
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8
Q

Describe the histology of the hyaline cartilage

A

Matrix has a “glassy” appearance because fibers and ground substance has the same refractive index

  • ECM correlates to function!
  • collagen
  • sulfates groups
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9
Q

What are the locations of hyaline cartilage?

A
  • Nose (cartilaginous portion)
  • Tracheal and bronchial rings
  • Laryngeal cartilages
  • Costal cartilages
  • Articular surfaces of long bones
  • Epiphyseal growth plate
  • Fetal skeleton
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10
Q

What is appositional growth?

A

Occurs from chondrogenic cells in the perichondrium differentiating into chondroblasts, forming a new layer of cartilage around the periphery of the existing cartilage
-This increases the width or thickness of the cartilage

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11
Q

What is interstitial growth?

A

Occurs only in young cartilage from cell divisions within the cartilage
-This increases the length of the cartilage

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12
Q

List in order of most influential first, what is the most influential hormones for growth?

A
  • Growth hormone
  • Thyroxine
  • Testosterone
  • Hydroxycortisone
  • Estradiol
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13
Q

Summarize regeneration 9f hyaline cartilage

A

Hyaline cartilage regenerates very poorly and often the perichondrium forms scar tissue

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14
Q

When dies hyaline cartilage calcify?

A

In old age hyaline cartilages can get calcified

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15
Q

Describe Articular cartilage

A

A type of hyaline cartilage found at Articular surfaces
-does not have perichondrium

It is in contact with Articular surface of bone on opposite side

  • Remnant of original cartilage template of developing bone
  • Persists throughout adult life
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16
Q

What are the various regions of Articular cartilages?

A
  1. Trans genital layer
  2. Transitional layer
  3. Radial layer
  4. Calcified layer
17
Q

What are elastic cartilage derived from?

A

Mesenchymal cells

18
Q

What are the cells of elastic cartilage?

A

Chondroblasts and Chondrocytes

19
Q

What is in the Extracellular matrix of elastic cartilage?

A
  • type 2 collagen fibers and elastic fibers

- GAGs and glycoproteins, multi-adhesive glycoproteins

20
Q

What kind of growth does elastic cartilage?

A

Appositional & interstitial growth

21
Q

Does elastic cartilage degenerate

A

Doesn’t readily degenerate

22
Q

Does elastic cartilage calcify?

A

Never calcify

23
Q

What is the function of elastic cartilage?

A

Support with flexibility

24
Q

What are the locations of elastic cartilage?

A
  • Pinna of the ear
  • external acoustic meatus
  • Eustachian tube
  • epiglottis

Is often found with hyaline cartilage

25
Q

Is perichondrium present in elastic cartilage?

A

Yes

26
Q

Contrast degeneration of elastic and hyaline cartilage

A

Does not degenerate as readily as hyaline cartilage

27
Q

Where is elastic cartilage found functionally?

A
  • located where support with flexibility is required
  • matrix is identical to that of hyaline cartilage, except it also contains a network of elastic fibers that impart to it a yellowish color on visualization of the gross specimen
28
Q

What are fibrocartilage derived from?

A

Mesenchymal cells

29
Q

What are cells of the fibrocartilage?

A

Fibroblasts transform to Chondrocytes under stress

30
Q

What is in the extracellular matrix of fibrocartilage ?

A
  • produced by Chondrocytes and fibroblasts
  • predominantly type 1 collagen fibers
  • also contains type 2 collagen fibers
  • GAGs- predominantly chondroitin and dermatan sulphates
31
Q

What kind of growth does fibrocartilage undergo?

A

Only interstitial growth (due to absence of perichondrium)

32
Q

What is the function of fubricartilage?

A

Resists deformation under stress (support and tensile strength)

33
Q

What are the locations of fibrocartilage?

A
  • Intervertebral disc (annulus fibrosus)
  • At the pubic symphysis
  • Medial and lateral menisci
  • Attachment of ligament to bone
  • Intersections of some tendons and ligaments
  • Articular discs
34
Q

What are the unique characteristics of fibrocartilage?

A
  • Absence of perichondrium
  • Matrix contains type 1 (mainly) & type 2 collagen fibers
  • These fibers can be seen here with H & E and trichromatic staining
  • Fibers arranged perpendicular to the direction of stress
  • Can undergo calcification
  • Isogenous groups are in linear fashion (longitudinal columns) due to the compression of collagen fibers
  • Doesn’t occur alone, but is found in conjunction with hyaline cartilage and other fibrous tissue