Integration of metabolism: a metabolic diary Flashcards

1
Q

what are the metabolic states?

A

fed

postabsorptive

fasting

starvation

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2
Q

fed state

A

3-6h after meal

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3
Q

postabsorptive state

A

3-6 - 12-18h after meal

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4
Q

fasting state

A

18h-2d

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5
Q

starvation

A

Fully adapted state of food deprivation lasting up to several weeks

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6
Q

what happens in the liver in the post absorptive state?

A

FA uptake

Alanine uptake

Glycerol uptake

Lactate uptake

Glycogenolysis

De novo glycogenesis

Triglyceride synthesis

FA ox

Glucose release

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7
Q

what happens in the muscle in the postabsorptive state?

A

Glucose uptake

Glycogenolysis

Triglyceride synthesis

FA ox

Transamination of create alanine

Alanine release

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8
Q

what happens in the adipose tissue in the postabsorptive state?

A

Lipolysis

FA release

Glycerol release

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9
Q

what happens in the brain in the postabsorptive state?

A

Glucose uptake

Glycolysis

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10
Q

breakfast

A

Consider a lazy day on holiday, plenty of food and not much ex

Breakfast is substantial meal with carb, protein and plenty of fat

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11
Q

what happens in the liver in the fed state?

A

FA uptake

Lactate uptake

Glucose uptake

AA uptake

Glycogen synthesis

Triglyceride synthesis

Protein synthesis

Glycolysis

Glucose release

VLDL release

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12
Q

what happens in the muscle in the fed state?

A

Glucose uptake

AA uptake

FA uptake

Glycolysis

Glycogen synthesis

Triglyceride synthesis

Protein synthesis

Lactate release

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13
Q

what happens in the adipose tissue in the fed state?

A

FA uptake

AA uptake

Glucose uptake

Triglyceride synthesis

Protein synthesis

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14
Q

what happens in the brain in the fed state?

A

Glucose uptake

AA uptake

Glycolysis

protein synthesis

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15
Q

an energetic day

A

Healthier day with a low-energy, mainly corn breakfast

h later subject goes for long slow jog

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16
Q

what happens in the brain during ex?

A

glucose uptake

glycolysis

ketone uptake

17
Q

what happens in the liver during ex?

A

glucose release

ketone release

gluconeogenesis

lactate uptake

alanine uptake

glycerol uptake

FA ox

18
Q

what happens in the muscle during ex?

A

FA uptake

glycogenolysis

lactate release

alanine release

glycerol release

19
Q

what happens in the adipose tissue during ex?

A

breakdown of TG

FA release

glycerol release

20
Q

what happens in the brain during the fasting state?

A

glucose uptake

glycolysis

21
Q

what happens in the liver during the fasting state?

A

glycogenolysis

glucose release

gluconeogenesis

lactate uptake

alanine uptake

glycerol uptake

FA ox

22
Q

what happens in the muscle during the fasting state?

A

glucose uptake

glycolysis

glycogenolysis

FA uptake

lactate release

alanine release

glycerol release

23
Q

what happens in the adipose tissue during the fasting state?

A

breakdown of TG

FA release

glycerol release

24
Q

starvation - ketogenesis

A

Lack of insulin

High rates of lipolysis and FA ox

Accumulation of acetyl coA

Low rates of ATP demand and CHO flux (glycerol-3-phosphate)

Synthesis of ketone bodies

Acetyl-CoA + Acetyl-CoA —> Acetoacetyl-CoA + CoA —> Acetoacetate (B-hydroxybutyrate and acetone)

25
Q

conversion of ketone bodies to acetyl-CoA

A

This happens in the muscle and the heart not the liver

Conversion of b-hydroxybutyrate into acetyl CoA

Muscle and heart will use the ketone bodies as fuels

Brain can use the ketone bodies in starvation

B-hydoxybutyrate —> acetoacetate —> acetoacetyl CoA —> Acetyl CoA