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AS - N926 Pharmacology > Insulins & Antidiabetics > Flashcards

Insulins & Antidiabetics Flashcards

1
Q

Very Rapid-Acting Insulin

A

Lispro
Insulin aspart
Glulisine

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2
Q

Very Rapid-Acting ONSET

A

5-15min

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3
Q

Very Rapid-Acting PEAK

A

45-75min

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4
Q

Very Rapid-Acting DURATION

A

2-4hr

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5
Q

Rapid-Acting Insulin

A

Regular

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6
Q

Rapid-Acting ONSET

A

30min

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7
Q

Rapid-Acting PEAK

A

2-4hr

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8
Q

Rapid-Acting DURATION

A

6-8hr

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9
Q

Intermediate-Acting Insulin

A

NPH

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10
Q

Intermediate-Acting ONSET

A

2hr

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11
Q

Intermediate-Acting PEAK

A

4-12hr

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12
Q

Intermediate-Acting DURATION

A

18-28hr

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13
Q

Long-Acting Insulin

A

Detemir

Glargine

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14
Q

Long-Acting ONSET

A

Detemir 2hr

Glargine 1.5hr

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15
Q

Long-Acting PEAK

A

Detemir 3-9hr

Glargine NONE

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16
Q

Long-Acting DURATION

A

Detemir 6-24hr

Glargine 20-24+hr

17
Q

Ultra Long-Acting Insulin

18
Q

Ultra Long-Acting ONSET

19
Q

Ultra Long-Acting PEAK

20
Q

Ultra Long-Acting DURATION

21
Q

Metformin MOA

A

Biguanide
Inhibits glucose production by the liver
↓GI glucose absorption
↑insulin sensitivity

22
Q

Metformin Anesthesia Implications

A

Discontinue 48hr prior to surgery

Monitor for lactic acidosis

23
Q

Sulfonylureas MOA

A

Stimulate insulin secretion & ↓insulin resistance ↑sensitivity
Sulfonylurea receptors on pancreatic & cardiac cells
Requires some β cell function

Glyburide, Glipizide, Glimepiride

24
Q

Sulfonylureas SE

A

Hypoglycemia more prolonged & dangerous than d/t insulin

25
Q

Sulfonylureas Anesthesia Implications

A

Discontinue 24-48hr preop

26
Q

Meglitinide MOA

A

Stimulate insulin secretion from β cells

Repaglinide & Nateglinide

27
Q

Meglitinide SE

A

Hypoglycemia risk

28
Q

α Glucosidase Inhibitors

A

Slow carbohydrate digestion & absorption

Interfere w/ glucosidase activity

29
Q

Thiazolidinedione(TZDs)

A

Increase sensitivity to insulin for glucose uptake by skeletal muscles & adipose tissue
↓insulin resistance

30
Q

Intraop Blood Glucose Management

A

Goal <180mg/dL

31
Q

Insulin Infusion

A

0.02-0.1u/kg/hr

32
Q

1unit Regular Insulin

A

↓plasma glucose by 25-30mg/dL

Monitor Q 30min-1hr

AS - N926 Pharmacology (18 decks)

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