Induction Agents Flashcards
Ideal Anesthetic Properties
Water-soluble Minimal cardiovascular or respiratory depression Lack toxicity or histamine release (hypersensitivity reactions) Rapid & smooth onset Rapid & smooth recovery Quick return to baseline mental status Rapid metabolism Steep dose-response curve Analgesia Anti-emetic action Bronchodilation Advantageous PK & PD
Propofol
Insoluble - requires lipid vehicle to emulsify
Supports bacterial growth
Not chiral
Pain on injection d/t phenol
No antagonist (married to the effects)
Rapid return to consciousness w/ minimal residual SE
Diprivan
pH 7-8.5
pKa 11
0.05% EDTA (ethylenediaminetetraacetic acid)
Propofol pH 4.5-6.4
pKa 11
0.025% sodium metabisulfite or benzyl alcohol
Propofol MOA
Selective GABA receptor modulator
GABA = inhibitory transmitter in CNS
Influx Cl¯ ions into cell resulting in cell hyperpolarization
Spinal motor neuron excitability not altered
Propofol PK
Clearances exceeds hepatic blood flow
1st pass pulmonary uptake
Extensive hepatic metabolism CYP450
Active metabolite 4-hydroxypropofol
Context sensitive half-time infusion <40min
NOT influenced by hepatic or renal dysfunction
↓ plasma clearance rate in patients older than 60
Binds reversibly to erythrocytes & plasma proteins, plasma albumin, free
Increase free fraction seen in severe hepatic/renal disease & pregnancy
Propofol PD
Rapid & pleasant loss & return to consciousness
Myoclonus induced secondary to disinhibition subcortical centers (less than etomidate)
Neuro protectant
Mild to moderate ↓ BP secondary to ↓ sympathetic tone & vasodilation & CNS, cardiac, & baroreceptor depression
Respiratory depression common in induction doses
Minimal bronchodilation
Propofol Induction
1.5-2.5mg/kg
Effects exaggerated w/ CV disease
↓ dose in elderly
↑ dose in pediatrics
Propofol Infusion
IV sedation 25-100mcg/kg/min
Prompt recovery w/out residual sedation (endoscopy)
Minimal/no analgesic properties
Used in conjunction w/ anxiolytic & opioid
Anesthesia maintenance
100-300mcg/kg/min
Associated w/ minimal post-op N/V
Used in conjunction w/ short-acting opioid
Propofol Other Doses
Antiemetic 10-15mg followed by 10mcg/kg/min infusion
Antipruritic 10mg
Anticonvulsant 1mg/kg
Propofol Contraindications
Hypersensitivity
Lipid metabolism disorder
Sulfate allergy (common in patients w/ asthma)
Caution in elderly, debilitated, & cardiac-compromised patients
PRIS
Long-term, high dose infusions
Associated w/ significant morbidity & mortality
MOA unknown
Seen in acute inflammatory disease - infection, sepsis, acute neurologic disease
Propofol triggering agent (catechol/steroids) administered
PRIS Risk Factors
> 4mg/kg/hr > 48hrs Critical illness High fat-low carb intake Concomitant catecholamine infusion Steroid administration Inborn mitochondrial fatty acid oxidation errors (creates oxygen supply-demand mismatch causing tissue necrosis)
Propofol S/S
Hypotension, bradycardia, widening QRS, Vtach or Vfib, asystole, ischemic EKG, arrhythmia, heart failure
Hypoxia & pulmonary edema
Acute kidney injury & hyperkalemia
Rhabdomyolysis
Hyperthermia, high anion gap metabolic acidosis, urine discoloration
Hepatomegaly, abnormal LFTs, steatosis, lipidemia, hypertriglyceridemia
Propofol Abuse
Addictive properties - develop tolerance & well-being on emergence
Incidence markedly increased over past 10yrs
Not controlled substance (facility dependent)
Etomidate
pH 8.1 pKa 4.2
Weak base
Water soluble in acidic pH; lipid soluble in physiologic
Preferable induction agent in unstable cardiac patient
Chemically unrelated to any other induction drug