Insulins

Question 1

rapid acting insulins

Answer 1

1. aspart (novolgo)
2. Lispro (Humalog)
3. Glulisine (Apidra)

Question 2

rapid acting insulins onset/peak/duration

Answer 2

Onset 5-15 min
Peak 30-60 min
Duration 2-4 hrs
-food in sight

Question 3

Short acting insulin

Answer 3

Regular U-100 U-500

Question 4

Regular U-100 U-500 onset/peak/duration

Answer 4

Onset 30-60 min
Peak 2-4 hrs
Duration 3-5 hrs
- 30 min premeal

Question 5

intermediate insulin

Answer 5

NPH (Novolin, Humulin N)

Question 6

NPH (Novolin, Humulin N) onset/peak/duration

Answer 6

Onset 1-2 hrs
Peak 6-12 hrs
Duration 18-24 hrs
- no r/tion to food

Question 7

Long acting insulins

Answer 7

• glargine (Lantus)

- Detemir (Levemir)

Question 8

Long acting insulins onset/peak/duration

Answer 8

Onset 1 hr
Peak no peak
Duration > 24 hrs
- no r/tion to food
-given same time each day

Question 9

Oral forms

Answer 9

1. glipizide

2. metformin

Question 10

glipizide onset/peak/duration

Answer 10

Onset 1-1.5 hrs
Peak 1-3 hrs
Duration 10- 24 hrs
- 30 min premeal

Question 11

metformin onset/peak/duration

Answer 11

Onset unknown half-life is 6.2 hrs
Peak 1-3 hrs
Duration 24 hrs
- with meal

Question 12

metformin/biguanides action/location

Answer 12

• decrease hepatic glucose output

- liver

Question 13

Sulfanylureas/ Meglitinides action/location

Answer 13

• increase insulin secretion(increase risk hypoglycemia)

- pancreas

Question 14

Thiazolidinediones TZDs action/location

Answer 14

• increase peripheral glucose uptake

- muscles

Question 15

Alpha-glucosides inhibitors action/location

Answer 15

• decrease glucose absorption
• acarbose
• in GI