Innate to adaptive immunity

Question 1

PAMP

Answer 1

pathogen associated molecular agent - foreign molecular structures

Question 2

DAMP

Answer 2

Damage associated molecular patterns

Question 3

PRR

Answer 3

Pattern recognition receptors

Question 4

TLR - and what it does

Answer 4

Toll like receptor have PRR - recognize PAMP and signals innate immune response - signal cascade –> expression of factors that cause/increase inflammation –> release cytokines/chemokines

Question 5

Common foreign patterns recognized by TLR

Answer 5

lipopeptides, zymosan, glycolipids, dsRNA (viral), endotoxins = lipoplysaccharides, flaggellin, ssRNA (viral), unmethylated CpG, asthma

Question 6

Final transcription factor most commonly activated in inflammation

Answer 6

NFkB

Question 7

Cytokine

Answer 7

small protein released by cell - chemokines, interferons, interleukins, lymphokines, tumour necrosis factor

Question 8

Chemokine

Answer 8

induce chemotaxis

Question 9

Function of Innate Immune response

Answer 9

Detect, Inactivation, destruction, removal of intruders

Question 10

Cell that bridge innate and adaptive

Answer 10

Dendritic Cell

Question 11

DC function

Answer 11

Dendritic Cell s in periphery -> activated via cytokines/chemokines -> travel to lymphatics to nearest lymph node -> antigen presenting cell to lymphocytes

Question 12

Compare speed: innate/adaptive

Answer 12

Innate faster - less powerful

Question 13

Adaptive immune response uses

Answer 13

antigens/antibody

Question 14

T cell matures in _____

Answer 14

thymus

Question 15

CTL cell is CD_?

Answer 15

8

Question 16

Th cells has CD_?

Answer 16

4

Question 17

5 classes of immunoglobin - antibodies

Answer 17

Ig: G, A, M , D, E

Question 18

Function of antibody

Answer 18

Bind to antigen - neutralize toxin, prevents microorganism from binding to its target cell

Question 19

Type 1 immunopathology

Answer 19

Immediate hypersensitivity - too much IgE - allergies, astham, anaphylactic shock –> mast cells degranulate/release histamine

Question 20

Type II immunopathology

Answer 20

Autoimmune due to antibodies - react against self - foreign antigen happens to look like self moelcule –> cross reaction

Question 21

Type III immunopathology

Answer 21

Antibody against a soluble antigen

Question 22

Systemic lupus erythematosus

Answer 22

makes antibody to own DNA

Question 23

Th1

Answer 23

pro-inflammatory - recruits macrophage

Question 24

Th17

Answer 24

More powerful than Th1, resist very though infection

Question 25

Th2

Answer 25

stimulate macrophage to become alternatively activated - walling off pathogen, promote healing. Typically after Th1 is done. Important in parasite

Question 26

Tfh

Answer 26

migrate from T cell in lymph to B cell follicles - activated B cell to switch classes

Question 27

Treg

Answer 27

make lymphokines - suppress activation/function of sibling T helper cells - keep immune response in cehck