Hematopoiesis

Question 1

Embryonal stage production in _______

Answer 1

yolk sac

Question 2

Fetal stage (___ -____ months) in _____

Answer 2

2-7 mo, liver, spleen

Question 3

Early childhood production in ____

Answer 3

long bones –> transitions to axial bones by teens

Question 4

Axial bones include ___, ___, ___, ___, ____

Answer 4

vetebrae, pelvis, sternum, ribs, skull

Question 5

Hematopoietic stem cells –> _________ cells –> _________ cells –> Mature cells

Answer 5

progenitor cells; precursors

Question 6

lymphoid includes

Answer 6

T cells, B cells, NK cells, and precursors

Question 7

Myeloid cells includes

Answer 7

Non-erythroid/non - lymphoid linages from marrow; Often (granulocytes, monocytes), megakaryocytes, platelets

Question 8

Life span of erythrocytes

Answer 8

120 days

Question 9

Pluripotential stem cell can make _________, and _______

Answer 9

self renewal (daughter self); progenitor cells

Question 10

Pluripotential stem cells includs (CFU-X)____ and ____

Answer 10

CFU-GEMM and CFU-L
(granulocytes/erthroid, monocytes, megakaryocyte); Lymphoids
CFU = colony forming units

Question 11

Progenitor cells are ____committed to differentiate along one or at most two linages

Answer 11

irreversibly

Question 12

CFU - GM

Answer 12

CFU granulocyte/macrophage

Question 13

CFU - M

Answer 13

monocyte

Question 14

CFU-E

Answer 14

Erthroid

Question 15

CFU-Meg

Answer 15

megakaryotes

Question 16

CFU-Eo and Baso

Answer 16

eosinophil/basophil

Question 17

BFU - E

Answer 17

Burst forming unit - erthyroid –> CFU - E

Question 18

Precursor cells are:

Answer 18

recognizable, maturing cells, can divide but not self renew

Question 19

Which cells can “self renew” and divide?

Answer 19

Hematopoietic stem cells, (multi-pluri potential stem cells), progenitor cells

Question 20

RBC hematopoiesis lineage from precursor

Answer 20

pronormoblast –> basophilic normoblast –> polychromatophilic normao blast –> orthochromatic normoblast (no replicate) –> Reticulocyte -> erythrocyte

Question 21

Pyknosis/karyopyknosis is ____________?

Answer 21

irreverisble condensation of chromatin

Question 22

Granulocyte maturation lineage from precursor

Answer 22

myeloblast –> promyeloctye –> metamyelocyte –> band –> segmented granulocytes (segs0

Question 23

platelet formation lineage from precursor

Answer 23

megakaryoblast –> promegakaryocyte –> megakaryocyte –> platelet

Question 24

Macrophage linage

Answer 24

monoblast –> promonocyte –> monocyte –> in tissues = macrophage

Question 25

HFG (hematopoietic growth factors - 7)

Answer 25

a. Erythropoietin (EPO) kidney to hypoxia  promotes erthyropoeisis b. Thrombopoietin (TPO) – promotes megakaryopoiesis c. Granulocyte-monocyte colony stimulating factor (GM-CSF) promotes granulopoiesis and monopoiesis d. Granulocyte colony stimulating factor (G-CSF) promotes granulopoiesis e. Monocyte colony stimulating factor (M-CSF) – monopoiesis f. Interleukin 5 (IL-5) – promote production with eosinophils g. Interleukin 3 (IL-3) – promotes production of basophils

Question 26

Life span of PMN

Answer 26

7 hours

Question 27

Life span of platelets

Answer 27

8.5 days

Question 28

marrow cellularity by age

Answer 28

100-age

Question 29

Hyperplastic marrow cellularity

Answer 29

increase proliferation of one or more lineages

Question 30

Aplastic marrow - define and cause

Answer 30

Marrow not there; autoimmune, viral (parvovirus B19), hematopoietic neoplasm, malnourished

Question 31

Path finding on boon marrow

Answer 31

marrow differential, cell morpholoyg, iron content, marrow celluarity, meyloid:erythroid ratio, megakaryocyte frequency, focal finidng