Innate to adaptive Flashcards
Y2C1 1 question will be asked
Cell comm
____used for comm
induce changes such as growth, differentiation movement or cell death
cytokines
Cytokines:types
what are the 4 types of cytokines
Chemokines
Interferons
Interleukins
Tumor necrosis factor
Cytokines:types
fill the blanks
chemokines
Interferons
Interleukins
Tumor necrosis factors
Cytokines:chemokines
Impo In___of immune cells
Chemotaxis
Cytokines:Interferons
_____proteins
impo role in control of____infections
also help regulate cells involved in____response
glycoproteins
viral infections
Immune
CYtokines:INterleukins
impo in____&___immunity,______
Innate adaptive inflammation
cytokines:tumor necrosis factor
help kill___cells
initiate_____
tumor cells
apoptosis
apoptosis:programmed cell death
lymphocyte subsets
guess the subsets
B cell
helper T cell
cytolytic T cell
NK cell
Natural killer cells
source:_____precursors
cytotoxic for
____cells
_____infected cells
other microorganisms
bone-marrow
tumor cells
viral infected cells
Natural cells
charateristic markers:CD___&___
T-cell markers:CD__,__,__
activated by cytokines:IF___,____,____ which causes IFN gamma secretion
do not carry__or__cell receptors
receptors both___&____
CD16&56
CD3-,4-,8-
IL-12,15,18
do not carry T or B cell receptor
both inhibitory & activatory
natural killer cells
IF-12,15 and 18 are NK cell____receptors
marker
IFN__&___causes Interferon response
alpha and beta
NK cell receptors:Inhibitory receptors
fill the blanks
normal cell
HLA-class I molecules
CD8+
Nk cell receptors:activatory receptors
recognize____or____antigens
virus or tumor
NK cell recognition:recognition patterns
fill the blanks
HLA-class I
NKG2D
antibody-dependant cell-mediated cytotoxicity
NK cells can attack tumor cells lacking____expression
HLA class I
NK cells prolong survival, but cannot prevent____
death
NKT cells
T-cells that have____cell marker(CD3+,CD56+)
release cytokines____&___after activation
Natural killer cell marker
IFN gamma & IL-4
gamma-delta T cells
part of first line of____defence
mature in___
found as_____lymphocytes
mostly in gut & oral mucosa
innate defence
intra-epithelial lymphocytes
gamma-delta T cells
recognize antigens other than____associated peptides(unlike CD_or_cells)
also works on___based antigens
HLA-associated
CD4+orCD8+ cells
works on lipid based
dendritic cells
develop in bone marrow from progenitor(CD_)cells or monocytes(CD__)
mostly found___of cell
CD34+ CD14+
enterance of cell
dendritic-cell maturation
epidermal dendritic cells are called____cells
langerhans
dendritic cells
which one is mature/Immature
Immature mature
Dendritic cells-major subtypes:myeloid dendritic cells
CD___,___
____marker
mainly in____tissues
major cytokines:___,___
major role in antigen presentation
CD11b+ CD14-
monocyte marker
TNF alpha, Il-6
other-antigen presenting cells:macrophages
express low___
inducable by___
present antigen to CD__cytotoxic T cells
HLA IFNy
CD8+
other-antigen presenting cells:B-cells
high___inducible by__
presents antigen to CD____helper cells
HLA Il-4
CD4+ T-helper cells
other antigen-presenting cells:vascular endothelial cells
low__ inducable by__
HLA IFNy
TNF and IL-1 are____cytokineses
preinflammatory
