Immunity to intracellular bacteria Flashcards

one part of Imune rsponses to infections pdf

1
Q

disease mechanisms for Intracellular bacteria

can survive and replicate within___
___&___cells,____cytes and_____are popular targets
elimination requires___mediated immunity__cells

A

endo end epithelial hepatocyte macrophage
cell mediated immunity T cells

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2
Q

Innate immunity:cells

____phils &___phages
___cells&___T cells

A

neutrophils&macrophages
gamma-delta T cells

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3
Q

Adaptive immunity:cells

___&___T cells
____formation

A

CD4+ & CD8+
granuloma formation

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4
Q

Type I IFN

plays role in____ immunity
2 types IFN_&_
secreted primarly by host cells infected with a___

A

Innate
IFN alpha and beta
virus

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5
Q

What raises during 0-4 days after viral infection

A

IFN-a&B
NK cells lvl raises

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6
Q

Type II IFN

IFN_
produced by_____and___Cells
later on produced by____cells

A

activated macrophages and natural killer cells
activated Th1 cells

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7
Q

Interferons and antiviral state

any of Type I and II IFNs can initiate____viral state in uninfected host cell

A

antiviral state

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8
Q

NK cell activation

virus causes downdregulation of MHC class_ on host cell surface
NK cells also imp mediators of _______

A

class I
antiviral adcc

adcc> antibody-dependent cellular cytotoxicity

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9
Q

Interferons

stimulate
direct cytolysis of____Cells
production of_____cytokines
upregulation of__receptors

A

infected cells
inflammatory cytokines
Fc receptors

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10
Q

Fc receptors

receptors found on natural killer cells that___bind
antibody form a bridge between_____cell and its target

A

Antibodies bind
Natural killer

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11
Q

Evasion strategies of Intracellular bacteria

can interfere with MHC class__
blocks assembly and expression of stable_______molecules and display of viral___
cannot be recognized or killed by____&____

A

MHC class-I molecules
viral peptides
CD8+&CTLs

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12
Q

Evasion strategies of intracellular bacteria:general tactics

latency
fooling___cells
Interference with______antigen presentation
Interference with___Cells
Interference w/___functions
avoiding_____

A

NK cells
MHC class-II antigen presentation
dendritic cells
antibody functions
complement

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13
Q

Evasion strategies of viruses

fill the blanks

A

IFN gamma
antiviral state
apoptosis
cytokines and chemokines
cytokine/chemokine transcription, receptor expression

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