Immunity to intracellular bacteria Flashcards
one part of Imune rsponses to infections pdf
disease mechanisms for Intracellular bacteria
can survive and replicate within___
___&___cells,____cytes and_____are popular targets
elimination requires___mediated immunity__cells
endo end epithelial hepatocyte macrophage
cell mediated immunity T cells
Innate immunity:cells
____phils &___phages
___cells&___T cells
neutrophils¯ophages
gamma-delta T cells
Adaptive immunity:cells
___&___T cells
____formation
CD4+ & CD8+
granuloma formation
Type I IFN
plays role in____ immunity
2 types IFN_&_
secreted primarly by host cells infected with a___
Innate
IFN alpha and beta
virus
What raises during 0-4 days after viral infection
IFN-a&B
NK cells lvl raises
Type II IFN
IFN_
produced by_____and___Cells
later on produced by____cells
activated macrophages and natural killer cells
activated Th1 cells
Interferons and antiviral state
any of Type I and II IFNs can initiate____viral state in uninfected host cell
antiviral state
NK cell activation
virus causes downdregulation of MHC class_ on host cell surface
NK cells also imp mediators of _______
class I
antiviral adcc
adcc> antibody-dependent cellular cytotoxicity
Interferons
stimulate
direct cytolysis of____Cells
production of_____cytokines
upregulation of__receptors
infected cells
inflammatory cytokines
Fc receptors
Fc receptors
receptors found on natural killer cells that___bind
antibody form a bridge between_____cell and its target
Antibodies bind
Natural killer
Evasion strategies of Intracellular bacteria
can interfere with MHC class__
blocks assembly and expression of stable_______molecules and display of viral___
cannot be recognized or killed by____&____
MHC class-I molecules
viral peptides
CD8+&CTLs
Evasion strategies of intracellular bacteria:general tactics
latency
fooling___cells
Interference with______antigen presentation
Interference with___Cells
Interference w/___functions
avoiding_____
NK cells
MHC class-II antigen presentation
dendritic cells
antibody functions
complement
Evasion strategies of viruses
fill the blanks
IFN gamma
antiviral state
apoptosis
cytokines and chemokines
cytokine/chemokine transcription, receptor expression
