Innate Immunity II Flashcards

1
Q

what occurs in the body if the chemical and physical barriers are successful in repelling a pathogen ?

A

pathogen encounter may not even be perceived by host

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what occurs when pathogen expands at greater rate than immediate defenses can eliminate?

A

soluble chemicals and cellular receptors develop and inflammation operates to allow entry of innate cells from the blood and temp rises

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what is PAMP?

A

pathogen associated molecular pattern, a conserved structure of a pathogen that is bound by an innate receptor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

which cells have innate receptors?

A
  1. cellular barrier cells like epithelial cells, keratinocytes, or endothelial cells
  2. immune cells like macrophages, dendritic cells, lymphocytes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

how do innate receptors trigger phagocytosis?

A

without signaling, except for signaling through toll-like receptors (TLR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what are innate receptors known as?

A

pattern recognition receptors (PRR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

which is the only innate receptor/PRR that causes signaling to occur?

A

TLR (toll like receptors)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

describe receptor mediated phagocytosis

A
  1. innate receptors bind microorganisms
  2. microorganisms are internalized by receptor mediated endocytosis
  3. endosome fuses with lysosome to form endolysosome where microorganisms are degraded
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

describe TLR

A

they are PRR with: extracellular domain for PAMP engagement that has leucine rich repeat region (LRR) AND cytoplasmic signaling domain Toll Interleukin 1 receptor TIR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what is the extracellular domain for TLR

A

leucine rich repeat region (LRR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is the cytoplasmic domain for TLR

A

toll interleukin 1 receptor (TIR)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what important TLR are located on the plasma membrane of innate cells?

A
  1. TLR4

2. TLR5

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

what important TLR are located in endosomes inside the cell?

A
  1. TLR3
  2. TLR7
  3. TLR9
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

which is TLR4 homodimer ‘s ligand?

A

lipopolysaccharide (LPS)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what microorganisms does TLR4 reconize?

A

gram negative bacteria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what cells express TLR4?

A
  1. macrophages
  2. dendritic cells
  3. mast cells
  4. eosinophils
17
Q

where is TLR4 located?

A

plasma membrane

18
Q

what is TLR7’s ligand?

A

single stranded viral RNAs

19
Q

what microorganism does TLR7 recognize?

A

RNA viruses

20
Q

what cells express TLR7?

A
  1. plasmacytoid dendritic cells
  2. NK cells
  3. eosinophils
  4. B cells
21
Q

where is TLR7 located?

22
Q

what is TLR9’s ligand?

A

unmethylated CpG-rich DNA

23
Q

what microorganism does TLR9 recognize?

A
  1. bacteria

2. DNA viruses

24
Q

what cells express TLR9

A
  1. plasmacytoid dendritic cells
  2. B cells
  3. eosinophils
  4. basophils
25
where is TLR9 located?
endosome
26
what is TLR3's ligand?
double stranded viral RNA
27
what microorganisms TLR3 recognize?
RNA viruses
28
what cells express TLR3?
NK cells
29
where are TLR3 located?
endosomes
30
what chromosome is TLR4?
9
31
what chromosome is TLR7?
X
32
what chromosome is TLR9?
3
33
what chromosome is TLR3?
4