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IMMUNO SERO - review > INNATE IMMUNITY > Flashcards

INNATE IMMUNITY Flashcards

1
Q

innate immunnity is

A

resist infection by means of normally present body functions

  • no prior exposure
  • lacks memory & specificity
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2
Q

response

A

immediate

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3
Q

3 lines of defense in the human body

A

1) First line of defense
2) Second line of defense
3) Third line of defense

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4
Q

external defense system

A

First line of defense

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5
Q

skin pH

A

pH 5.5 to 5.6

ave. 5.6

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6
Q

phenomenon that normal flora keeps other microorganisms from establishin in areas of the body

A

Competitive exclusion

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7
Q

internal defense system in which both cells and soluble factors play essential parts

A

2nd line of defense (innate immunity)

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8
Q

composition of 2nd line of defense (innate immunity)

A

phagocytosis, inflammation, APRs, antimicrobial substances(complement, properdin, interferon alpha & beta, TNF, betalysin)

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9
Q

cellular components of 2nd line of defense (innate immunity)

A

mast cells
macrophage
neutrophils
NK cells

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10
Q

humoral component of

A

complement
lysozyme
interferon

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11
Q

mechanism that allows recognize, remember, and respond to a specific stimulus

A

Third line of defense (Acquired immunity)

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12
Q

cellular component of Third line of defense (Acquired immunity)

A

t lymp, b lymp, plasma cell

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13
Q

humoral component of Third line of defense (Acquired immunity)

A

antibodies and cytokines

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14
Q

normal serum constituents that increase rapidly by at least 25% due to infection, injury or trauma to the tissues

A

Acute phase Reactants

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15
Q

site of production of APRs

A

hepatocytes

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16
Q

cytokines are

A

intracellular signalling polypeptides

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17
Q

indicator of inflammation

A

APRs

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18
Q

APR/s that increase 1000x

A

CRP

Serum amyloid A

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19
Q

Nonspceific indicator of inflammation

A

CRP

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20
Q

CRP marker for

A

cardiac

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21
Q

thought to be an antibody to the c-polysacharide of the pneumococci

A

CRP

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22
Q

significant risk factor for myocardial infarction and ischemic stroke

A

HS-CRP

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23
Q

Regulates removal/metabolism of cholesterol

A

Serum amyloid A

24
Q

decrease value of Alpha 1-antitrypsin

A

emphysema & Juvenile cirrhosis

25
Q

ceruloplasmin function/s

A
  1. transport copper

2. acts as Ferroxidase

26
Q

depletion of ceruloplasmin found in what condition?

A

Wilson’s disease

27
Q

can convert ferrous iron(Fe2+) to ferric iron (Fe3+)

A

Ferroxidase

28
Q

overall reaction of the body to injury or invasion by a infectious agent

A

Inflammation

29
Q

primary inflammatory response

A

Vasodilation

30
Q

increase in cappilary permeability

A

Vasodilation

31
Q

movement of WBC through squeezing

A

diapedesis

32
Q

stages of inflammation

A
  1. Vascular response
  2. Cellular response
  3. Resolution & repair
33
Q

resolution & repair is initiated by

A

fibroblast

34
Q

5 cardinal signs of inflammation

A
  1. rubor (redness)-inc. blood flow
  2. Dolor (pain) - nerve is pressed
  3. Calor (heat)
  4. Tumor (swelling) - edema
  5. Functio laesa (loss of function)
35
Q

starfish larvae

A

phagocytosis is observed here by Elli Metchnikoff

36
Q

phagocytic cells

A
  1. Basophils
  2. Eosinophils
  3. Neutrophils
  4. Monocytes
  5. Macrophages
  6. dendritic cells
37
Q

phagocytosis is initiated as a result of

A

tissue damage

38
Q

most efficient phagocytic cells

A

Dendritic cells

39
Q

coating of cells

-“to prepare for eating”

A

opsonization

40
Q

movement of cells to certain direction under stimulation of a chemical substance such as opsonin

A

Chemotaxis

41
Q

test for chemotaxis

A

Boyden Chamber assay

42
Q

last stage of phagocytosis

A

DIGESTION /

Formation of neutrophil extracellular traps

43
Q 
ABNORMAL = chemotactive activity
NORMAL = Random activity
A

Job syndrome

44
Q

ABNORMAL BOTH = Chemotactic activity & Random activity

A

Lazy leukocyte

45
Q

microorganism inside the cytoplasm of cell

A

phagosome

46
Q

strongest mechanism to kill microorganism

A

Oxygen dependent/ Respiratory burst

47
Q

a disease that has impaired respiratory burst/ deficiency of NADPH oxidase

A

Chronic Granulomatous disease (CGD)

48
Q

3 TYPES OF DENDRITIC CELLS

A
  1. Langerhan cells
  2. interdigitating dendritic cells
  3. interstitial dendrtic cells
49
Q

dendritic cells of hollow organs

A

interstitial dendrtic cells

50
Q

dendritic cells in lymphoid tissues

A

interdigitating dendritic cells

51
Q

dendritic cells in skin

A

Langerhan cells

52
Q

fusion of phagosome with lysosomal granules

A

phagolysosome

53
Q

transmembrane recptor that recognize different types of PAMPS

A

Toll-Like Receptors (TLRs)

54
Q

large groups of microorganisms recognized by PRRs

A

Pathogen-associated molecular patterns (PAMPS)

55
Q

antibody must attach to the ____ region for the microorganisms to bephagocytosed

A

Fc portion/region

56
Q

immune complex

A

Ag-Ab formed

IMMUNO SERO - review (4 decks)

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