HISTORY

Question 1

IMMUNOLOGY

Answer 1

• study of our IMMUNE SYSTEM

- Study of host’s reactions when foreign antigens are INTRODUCED to the body

Question 2

Smallpox vaccine;

observed milkmaids

Answer 2

Edward Jenner (1798)

Question 3

founder of immunity

attenuation of Rabies (1885)

Answer 3

Louis Pasteur (1868)

Question 4

“vaccinia”

Answer 4

cowpox

*vacc = vacca = baka

Question 5

“variola”

Answer 5

smallpox

Question 6

Phagocytosis

cellular theory of immunity

Answer 6

Elli Metchnikoff (1880 - 1900)

Question 7

complement fixation

Answer 7

Bordet and Gengou (1901)

Question 8

Grabar and Williams (1952 - 1953)

Answer 8

immunoelectrophoresis in gel analysis

Question 9

template theory of antibody production

Answer 9

Friedrich Brent/ 
Felix Haurowitz (1930)

Question 10

Clonal Selection Theory

Answer 10

Niels Jerne/ Frank Burnet (1955 - 1957)

Question 11

Histocompatibility Complex

Answer 11

Dausset/Rapoport (1958)

Question 12

Milstein and Kohler (1973)

Answer 12

Hybridoma for the production of Monoclonal Antibodies

Question 13

Chinese practice of inhaling powder (smallpox scabs)

• “exposing”
• some people develop the dse.
• also used in TB and Syphilis

Answer 13

Variolation

Question 14

exact antibody binding site

Answer 14

Epitope

Question 15

occurs when an antibody reacts with antigen that is structurally similar to the original antigen

• the Ag has the same binding site

Answer 15

Cross reactivity

Question 16

eradication of smallpox, no cases since_____

Answer 16

1977

Question 17

parasite near in eradication

Answer 17

Dracunculus medinensis

• “Dragonomous/fiery serpent”
• causing you to “burn” alive

Question 18

stocks of Variola virus for research found in?

Answer 18

1) CDC - Atlanta, Georgia

2) VECTOR Institute - Koltsovo, Russia

Question 19

Make a pathogen less virulent

Answer 19

Attenuation

Question 20

Diptheria and tetanus toxin

Answer 20

Emil von Behring

Question 21

Opsonins

Answer 21

Almroth Wright

Question 22

• immunized rabbit with haptens
• three dimensional configuration
• ABO blood group

Answer 22

Karl Landsteiner

Question 23

designed to keep microorganisms from entering the body

Answer 23

Anatomical barriers

Question 24

Humoral includes

Answer 24

APRs, Interferons A & B, Defensins, Complement proteins

Question 25

basophils and mast cells are differentiated by

Answer 25

GRANULE CONTENT

Question 26

Father of Immunology

Answer 26

Louis Pasteur

Question 27

weakened live pathogens

Answer 27

Attenuated vaccine

Question 28

killed microorganisms

Answer 28

Inactivated vaccine

Question 29

tetanus is what type of vaccine

Answer 29

toxoid

Question 30

other person who is said to have discovered Phagocytosis in 1798

Answer 30

Haeckel

Question 31

T cell receptor gene year of discovery

Answer 31

1984

Question 32

Complement

Answer 32

Jules Bordet

Question 33

book of Karl Landsteiner

Answer 33

SSR = specificity of serological reaction

Question 34

ABO blood group discovery

Answer 34

Karl Landsteiner

Question 35

Radioimmunoassay (RIA)

Answer 35

Rosalyn Yallow

Question 36

Structure of antibodies

Answer 36

Gerald Edelman & Rodney Porter

Question 37

Antibody diversity

Answer 37

Susumu Tonegawa

Question 38

one agent produces protection against another agent is known as

Answer 38

Cross-immunity

Question 39

Cross-immunity is discovered by

Answer 39

Edward Jenner