ADAPTIVE IMMUNITY Flashcards
Goal of adaptive immunity
Antibody production
antigen is introduced
Active immunity
antibody is introduced
Passive immunity
infection, natural exposure
Natural active
vaccination
Articial active
mother to fetus
natural passive
injection of artificial sera/antibody
artificial passive
yellowish milk from mother
Colostrum
2 types of adaptive immunity
- Humoral branch
2. Cellular branch
Cellular branch
- T lymphocytes
- viral and fungal infections
Humoral branch
- B lymphocytes
- primary defense against bacterial infection
lymphocyte not involved in adaptive immunity
NK Cells
not an end cell
lymphocyte
site of maturation of T cell
thymus
site of maturation of B cell
Bone marrow
site for antigen dependent lymphopoiesis
Secondary lymphoid organs
site of spleen that contains mainly of T cells only
PALS (Periarteriolar lymphoid sheaths
antigen independent lymphopoiesis
Bone marrow
thymocytes
immature T cells
site of lymph nodes that contains mainly of t cells
Paracortex
site of B cells in lymph nodes
Follicles & germinal centers
MALT
Mucocutaneous Associated Lymphoid Tissue
CALT
Cutaneous Associated Lymphoid Tissue
represents 60 to 80% of circulating lymphocytes in the peripheral blood
T Lymphocytes
NORMAL Ratio of CD 4+: CD 8+ cells
2:1
in HIV, ratio of CD 4+ : CD 8+ cells
1:2 or 0.5:1
AIDS CD 4+ cell count
< 200 cells /uL
receptor for MHC Class II molecules
CD 4
receptor for MHC Class I
CD 8
Part of T cell antigen-receptor complex
CD 3