Innate Immunity Flashcards
This in the bone marrow makes B cells and T cells in the blood?
Common lymphoid progenitor
These immune cells occur primarily in tissues? (3)
Macrophages
Dendritic cells
Mast cells
This makes the Granulocyte/Macrophage progenitor which then produces neutrophils, eosinophils, basophils, monocytes, immature dendritic cells in the blood?
*mast cell, macrophage, immature dendritic cells in?
Common myeloid progenitor
Tissues
Immature dendritic cells will become mature dendritic cells when something scares them - go to?
Lymph nodes
The Humoral Innate Immune System will have these cells looking for non-host epitopes?
*Fast, but not the best way to fight infection
Macrophages and Neutrophils (Myeloid cells)
The Humoral Adaptive Immune System uses these cells to produce antibodies. They are looking for an amino acid sequence on a protein that is not found on any of our proteins.
*Very specific, powerful, but it takes awhile
B cells
The Cell-Mediated Adaptive Immune System uses these cells which use MHC1 and T cell receptors in order to look for host cells to kill.
Cytotoxic T cells (Tc, CD8)
These molecules allow immune cells to communicate with other immune cells…or other cells?
Ex: Macrophages use this to signal endothelial cells to retract
Cytokines
Released by macrophages in response to bacteria in extracellular space
These tell immune cells where to go and how to get there?
Ex: neutrophils follow their gradient
Chemokines
Released by macrophages in response to bacteria in extracellular space
This also has macrophages to eat old RBCs.
*Theory: RBCs have to get through dashed circle of death in order to get back into circulation. This area is inhabited with macrophages.
Spleen
Antigen uptake in peripheral sites.
Antigen presentation in lymph nodes.
Dendritic cells
cell of innate immunity
Phagocytosis and activation of bactericidal mechanisms.
Neutrophils
cells of innate immunity
Killing of antibody-coated parasites. Useful against parasitic worms.
Eosinophils
cells of innate immunity
Release of granules containing histamine and other active agents.
Use against allergies.
*We don’t know what basophils do.
Mast cells
cells of innate immunity
Phagocytosis and activation of bacterial mechanisms.
Antigen presentation.
Macrophages
cells of innate immunity
These have a weird shaped nucleus because it is a lot easier to get it through a smaller space (slithers through endothelial cell gaps to fight bacteria in ISF)
-Neutrophils
Movement of neutrophils by diapedesis through capillary pores and by ____ toward an area of tissue damage.
*Following chemokine gradient which is where the macrophage is that set off the alarm - where bacteria is
Chemotaxis
Non-host epitopes (pattern on a bacteria that we would never find on one of our cells). We can use these to identify bacteria, but remember bacteria will have as few of these as possible.
*One way to phagocytose bacteria. Another is with antibody.
Pathogen associated molecular pattern (PAMP)
The passage of blood cells through the intact walls of the capillaries, typically accompanying inflammation.
Diapedesis
We have ______ so we can concentrate pathogens in an easy place to find them.
*B cells and T cells looking for their antigen, go to lymph nodes to check it out
lymphatic drainage
Lymph draining from all of our tissues. Only one organ that does not have lymphatic drainage?
____ does not have lymph nodes but it does have lymphatic drainage (cervical lymph nodes).
Kidney
Brain
Lymph node for the blood?
-If we have an infectious agent in the blood needs to go through here.
These cells will scan blood here looking for antigens?
Spleen
T cells and B cells
Responsible for stopping the neutrophils - located on endothelial cells
ICAM
Movement of neutrophils by ____ through capillary pores and by ____ toward an area of tissue damage.
Diapedesis
Chemotaxis
