Innate Immunity

Question 1

Detail the molecular components of innate defences. (First list all of them, then outline them)

Question 2

Explain the acute phase response (draw also).

Question 3

Explain the complement system (draw also).

Question 4

Explain the regulation of complement activation.

Question 5

Discuss the recognition mechanisms of innate immunity(e.g. TLRs).

Question 6

List and outline at least 5 cells of innate immunity.

Answer 6

Neutrophils;
Macrophages;
Mast cells;
Eosinophils;
Dendritic cells;

Question 7

Detail phagocytic cell responses.

Question 8

Macrophages secret pro-inflammatory cytokines, what are they? Outline their respective functions in immunity.

Question 9

Give examples of inflammatory mediators and their roles in inflammation.

Question 10

Name a describe the function of 2 proteins of inflammation.

Question 11

Why are anti-inflammatories important? Give examples of anti-inflammatories.

Question 12

Give an example of a disease associated with innate defects.

Question 13

What are the clinical consequences of uncontrolled inflammation?

Question 14

Explain general immune response with respect to blood vasculature.