Hypersensitivty

Question 1

Define antigen, antibody, and allergen.

Question 2

Define/outline hypersensitive reactions.

Answer 2

• Mobilisation of the immune response,
  normally results in Ag elimination without extensive damage to host tissues or interference of normal life processes, this response can in some causes cause tissue damage or death.
  
  • Can develop in the course of both humoral and cell-mediated responses.
  • Rapid, massive response termed anaphylaxis. Anaphylaxis is immediate hypersensitivity, but hypersensitivity can develop over days (delayed type hypersensitivity).

Question 3

List the types of hypersensitivities.

Question 4

Discuss type 1 hypersensitivity, include an explanation/illustration of the mechanism.

Question 5

Discuss type 2 hypersensitivity, include an explanation/illustration of the mechanism.

Question 6

Discuss type 3 hypersensitivity, include an explanation/illustration of the mechanism.

Question 7

Discuss type 4 hypersensitivity, include an explanation/illustration of the mechanism.

Question 8

Define anaphylaxis and discuss its mechanism/relevance.

Question 9

Define/differentiate between systemic and local anaphylaxis.

Question 10

Define/discuss atopy, use asthma as an example and discuss the mechanism.

Question 11

What is ADCC associated within terms of disease, procedures, and reactions.

Question 12

Detail the immunological issue behind HDFN, include an illustration(?)

Question 13

Define/outline the systemic and generalised type of type 3 hypersensitivity.

Question 14

Describe an example of type 3 hypersensitivity.

Question 15

List/define the types of transplantation.

Question 16

What is the main concern when considering transplantation?

Question 17

How is similarity and similarity of recipient and donor determined? List the 3 methods.

Question 18

Discuss MLR.

Question 19

Discuss serological testing for transplantation.