Innate Immune System Cells - Week 4 PBL

Question 1

What are neutrophils and what is their role?

Answer 1

Innate immune cell
Can phagocytose
First cell to arrive at infection or inflammation site
Neutrophils die after killing pathogen = Pus

Question 2

How are neutrophils activated ?

Answer 2

By IL8 and TNF via macrophages
By IL17 by T cells in adapted immune system

Question 3

What are mast cells and their role?

Answer 3

Discharging their granule contents - activated by IgE

Attacks larger living organisms like tapeworms

Mast cell activation = leukotrienes = eosinophil attraction to parasites

Question 4

What’s the role of basophils and what do they do?

Answer 4

Activated by IgE - release histamine and LCT4

Question 5

What are eosinophils and their role?

Answer 5

Release cytokines and messenger molecules
Good for multicellular parasite infection

Question 6

What are monocytes and macrophages and their role?

Answer 6

Monocytes differentiate into macrophages
Phagocytose and cytokine production

Longer lived cells

Question 7

What types of cytokines do macrophages secrete?

Answer 7

TNF IL8 and IL1

Question 8

How are macrophages activated?

Answer 8

Cytokines like IFN-Y
Complement

Question 9

What are natural killer cells?

Answer 9

Large granular cytotoxic lymphocytes
In innate immune response
Induce apoptosis in target cells