iNKTs

Question 1

iNKTs represent ___% of hepatic T cells.

Answer 1

iNKTs represent 30% of hepatic T cells.

Question 2

iNKTs branch off of the conventional T cell development pathway at the ___ stage of T cell development.

Answer 2

iNKTs branch off of the conventional T cell development pathway at the CD4⁺ CD8⁺ stage of T cell development.

Question 3

___ regulates the ability of iNKTs to secrete cytokines.

Answer 3

GM-CSF regulates the ability of iNKTs to secrete cytokines.

Interestingly, it does not affect proliferation.

Question 4

____ has a role in regulating iNKT emigration from the thymus.

Answer 4

lymphotoxin has a role in regulating iNKT emigration from the thymus.

Question 5

iNKT selection

Answer 5

selected for positive recognition of CD1d loaded with α​-galactosylcerebroside on the surface of other CD4⁺ CD8^{<strong>+</strong>} cells.

Question 6

The role of TGF-β in the thymus is primarily. . .

Answer 6

. . . to act as a growth factor for iNKTs.