Adult-Onset Immunodeficiency Syndrome

Question 1

What is adult-onset immunodeficiency syndrome?

Answer 1

An acquired immunodeficiency caused by anti-interferon gamma antibodies.

Typical onset is 30-50 years of age, slightly more common in people of Southeast Asian heritage.

Question 2

Typical course of an AOIS patient

Answer 2

Fine until adulthood, but then develop recurrent atypical mycobacterial, non-typhoidal salmonella, Penicillium marneffei, CMV, and VZV infections.