Inhibitors of catecholamie storage

Question 1

What are the major inhibitors of catecholamine storage?

Answer 1

Tyramine

Resperine

Guanethidine

Amphetamine

Methylphenidate

Pseudoephedrine/ephedrine

Methamphetamine

Question 2

Which inhibitors of catacholamine storage are used in the treatment of HTN and what is their MOA?

Answer 2

• Respirine (irreversibly inhibit VMAT)
• Guanethidine (displaces norepinepherine)

Tyramine (displaces norepinepherine)

Question 3

What is the clinical significant of tyramine?

Answer 3

• After being incorporated into the vesicles is can be converted to octopamine which is a long lived metabolite
• octopamine can cause severe postural hypotension

Question 4

Which inhibitors of catecholamine storage is commonly used in the treatment of ADHD? What is its MOA (3)?

Answer 4

• Amphetamine and methylphenidate
• Weakly inhibits MAO, displaces endogenoud catecholamines in the vesicles, blocks reuptake by NET

Question 5

What is the clinical uses of ephedrine and psuedoephedrine?

Answer 5

Ephedrine: persistant hypostension

-pseudo: nasal decongestant

Question 6

What is an addictive drug of abuse that is a catecholamine stoage inhibitor?

Answer 6

Methamphetamine

Question 7

What are 2 MAO inhibitors? One is nonselective and the other is selective (for what?).

Answer 7

Phenelzine (non-selective)

Selegiline (MAO-B selective)

Question 8

What transporter does cocain inhibit?

Answer 8

NET