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Pharmacology > Chapter 8 > Flashcards

Chapter 8 Flashcards

1
Q

Acetylcholine Receptor taget and MOA

A
  • Nicotinic
    • Increases:
      • Na+, Ca+, K+ conductance
  • Muscarinic
    • Increases
      • IP3/DAG/Ca
      • K+ conuctance
    • Decreases:
      • cAMP
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2
Q

GABA receptor and MOA

A

Receptor: GABAa, GABAb

Mechanism:

  • GABAa
    • Decreases cAMP
  • GABAb
    • Increases
      • Cl- and K+ conductance
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3
Q

Glutamate Receptor type and MOA

A

Receptor:

  • AMPA
  • Kainate
  • NMDA
  • mGlu(1-7)

Mechanism:

  • Increases:
    • Na+ and K+ conductance
    • IP3/DAG/Ca+
  • Decreases
    • cAMP
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4
Q

Dopamine recptor and MOA

A
  • D1, D5
    • Increases cAMP
  • D2, D3, D4
    • Increases K+, Lowers cAMP and Ca Conductance
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5
Q

Norepinepherine Receptors and MOA

A
  • alpha1
    • Increases IP3/DAG/Ca2+
  • alpha2
    • Decreases cAMP and Ca conductance
    • Increases K+
  • beta1,2,3
    • Increase cAMP
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6
Q

Serotonin Receptor and MOA

A
  • 5-HT1
    • Decreases cAMP
    • Increases K+ Conductance
  • 5-HT2
    • Increases IP3/DAG/Ca
  • 5-HT3
    • Increases Na and K conductance
  • 5-HT4-7
    • Increases cAMP
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7
Q

Histamine receptor and MOA

A
  • H1
    • Increases IP3/DAG/Ca
  • H2
    • Increases cAMP
  • H3
    • unknown
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8
Q

What are the the Catecholamines and what molecule are they all based off of?

A
  • Dopamine
  • Norepinepherine
  • Epinepherine
  • All based off of Tyrosine
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9
Q

What molecule is the origin of serotnin?

A

Serotonin (5-hydroxytryptamine), originated from tryptophan.

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10
Q

How is histamine formed?

A

-by the decarboxylation of Histidine

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11
Q

What are multiple drug resistance (MDR) transporters

A

Transprters in the BBB that pump hydrophillic compounds back out into the vessel lumen.

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12
Q

What is long-tract neuronal organization?

A
  • Neural pathways that connect at distant areas of the nervous system to one another.
  • used by the periferal nervous system
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13
Q

What i ther difference between divergent and convergent signaling?

A
  • divergent: whwn one neron makes connections to several thousand postganglionics
  • Convergent: Many upstream signal received and consolidated.
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14
Q

What kind of connection is involved in signal modulation?

A

-local circuit organization

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15
Q

What kind of neuronal organization predominates in the brainstem, hypothalamus, and basal forebran?

A
  • Signle source divergent signaling
  • commonly referred to as diffuse system of organization
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16
Q

What is the origin of Dopaminergic Neurons?

A

Substantia Nigra

17
Q

Where do noradrenergic (norepi) neurons originate?

A

The locus ceruleus

18
Q

Where do serotonin type neurons originate? What do they normally preceive?

A
  • Raphe Nuclei
  • preception of pain

Pharmacology (17 decks)

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