Chapter 8 Flashcards
Acetylcholine Receptor taget and MOA
- Nicotinic
- Increases:
- Na+, Ca+, K+ conductance
- Increases:
- Muscarinic
- Increases
- IP3/DAG/Ca
- K+ conuctance
- Decreases:
- cAMP
- Increases
GABA receptor and MOA
Receptor: GABAa, GABAb
Mechanism:
- GABAa
- Decreases cAMP
- GABAb
- Increases
- Cl- and K+ conductance
- Increases
Glutamate Receptor type and MOA
Receptor:
- AMPA
- Kainate
- NMDA
- mGlu(1-7)
Mechanism:
- Increases:
- Na+ and K+ conductance
- IP3/DAG/Ca+
- Decreases
- cAMP
Dopamine recptor and MOA
- D1, D5
- Increases cAMP
- D2, D3, D4
- Increases K+, Lowers cAMP and Ca Conductance
Norepinepherine Receptors and MOA
- alpha1
- Increases IP3/DAG/Ca2+
- alpha2
- Decreases cAMP and Ca conductance
- Increases K+
- beta1,2,3
- Increase cAMP
Serotonin Receptor and MOA
- 5-HT1
- Decreases cAMP
- Increases K+ Conductance
- 5-HT2
- Increases IP3/DAG/Ca
- 5-HT3
- Increases Na and K conductance
- 5-HT4-7
- Increases cAMP
Histamine receptor and MOA
- H1
- Increases IP3/DAG/Ca
- H2
- Increases cAMP
- H3
- unknown
What are the the Catecholamines and what molecule are they all based off of?
- Dopamine
- Norepinepherine
- Epinepherine
- All based off of Tyrosine
What molecule is the origin of serotnin?
Serotonin (5-hydroxytryptamine), originated from tryptophan.
How is histamine formed?
-by the decarboxylation of Histidine
What are multiple drug resistance (MDR) transporters
Transprters in the BBB that pump hydrophillic compounds back out into the vessel lumen.
What is long-tract neuronal organization?
- Neural pathways that connect at distant areas of the nervous system to one another.
- used by the periferal nervous system
What i ther difference between divergent and convergent signaling?
- divergent: whwn one neron makes connections to several thousand postganglionics
- Convergent: Many upstream signal received and consolidated.
What kind of connection is involved in signal modulation?
-local circuit organization
What kind of neuronal organization predominates in the brainstem, hypothalamus, and basal forebran?
- Signle source divergent signaling
- commonly referred to as diffuse system of organization
What is the origin of Dopaminergic Neurons?
Substantia Nigra
Where do noradrenergic (norepi) neurons originate?
The locus ceruleus
Where do serotonin type neurons originate? What do they normally preceive?
- Raphe Nuclei
- preception of pain
