Inhibitors of Acetylcholine degredation Flashcards
1
Q
What is the mechanism of action of inhibitors of ACh degredation?
A
Inhibit AChE by binding tot he active site.
2
Q
What drug is the short acting drug of choice to diagnose Myasthenia gravis, Eaton-lamert and others?
A
Edrophonium
3
Q
What 2 AChE inhibitors are used to induce GI motility in diseases like MG?
A
Neostigmine
Pyrodostigmine
4
Q
Which drug is used for the same purposes but slower acting that neostigmine?
A
Physostigmine
5
Q
Which drugs phosphorylates AChE and results in a long term inhibition that is subject to the process of Aging and virtually irresversible inhibition?
A
-Diisopropyl fluorophosphates
6
Q
Which 4 drugs are AChE inhibitors that are indicated for the treatment of mild and moderate AD?
A
- Tacrine
- Denepezil
- Rivastigmine
- Galantamine
