Inhibitors Of Angiotensin Flashcards
Has vasoconstrictor and Na retaining properties
Angiotensin II
Stimulate aldosterone release
Angiotensin II and III
Inhibits ACE and inactivates bradykinin, a potent vasodilator.
Captopril and other ACE inhibitors.
Hypotensive activity from this drug results both from inhibitory action on the RAAS and stimulating tha activity of kallikrein kinin system.
Captopril
Oral prodrug that is converted by hydrolysis to active ACE inhibitor enalaprilat with effects similar to captorpril.
Enalapril
Lysine derivative of enalaprilat.
Lisinopril
Lower bp primarily by decreasing PVR. CO and HR are not significantly changed. Do not result in reflex sympathetic activation and can be used in persons with ischemic heart disease.
Angiotensin II inhibitors
All ACE INHIBITORS EXCEPT FOSINOPRIL AND MOEXIPRIL ARE ELIMINATED IN THE
Kidneys