B Adrenoreceptor Blocking Agents

Question 1

Especially useful in preventing repflex tachycardia that often results from treatment with direct vasodilators.

Answer 1

B blockers

Question 2

Reduce mortality after MI and heart failure

Answer 2

B blockers

Question 3

Non selctive B blockade and decrease bp primarily through decreasing cardiac output

Answer 3

Propranolol

Question 4

Inhibits stimulation of renin production by catecholamines(B1 receptors)

Answer 4

Propranolol

Question 5

Might also act on peripheral presynaptic B andrenoreceptors to reduce sympathetic vasoconstrictor nerve activity

Answer 5

B blockers

Question 6

Produces significant reduction in bp without prominent postural hypotension in patients with mild to mederate hypertension

Answer 6

Propranolol

Question 7

Indicators or propranolol B blocking effect

Answer 7

Resting bradycardia and reduction in HR

Question 8

Principal toxicities of this drug result from blockade of cardiac, vascular and bronchial B receptors

Answer 8

Propranolol

Question 9

Produces a withrawal sundrome characterized by nervousness, tachycardia, increased intensity of angina and increased bp caused by upregulation or supersensitivity of B receptors

Answer 9

Propranolol

Question 10

These drugs are cardioselective and are the most widely used B blockers in the treatment of hypertension

Answer 10

Metoprolol and atenolol

Question 11

Equipotent to propranolol in inhibiting stimulation of B1 receptors as those in the heart but much less potent in blocking B2 receptors. Cardioselectivity is incomplete and is extensively metabolized by CYP2D6.

Answer 11

Metoprolol

Question 12

Effective in reducing mortality from heart failure and particularly useful in patient with hypertension and heart failure.

Answer 12

Metoprolol and Carvedilol

Question 13

Cardioselective B blocker that is excreted primarily in the urine

Answer 13

Atenolol

Question 14

Non selective B receptor antagonists and excreted to a considerable extent in the urine

Answer 14

Nadolol and carteolol

Question 15

B1 selective blockers that are primarily metabolized by the liver but have long half lives. Taken once daily

Answer 15

Betaxolol and bisoprolol

Question 16

Partial agonist B blockers with some intrinsic sympathomimetic activity. They lower bp by decreasing vascular resistance and appear to depress cardiac output or heart rate less than other B blockers perhaps because of significantly greater agonist than antagonist effects on B2 receptors.

Answer 16

Pindolol, acebutolol, and penbutolol

Question 17

Beneficial for patients with bradyarrhythmias or peripheral vascular disease.

Answer 17

Pindolol, acebutolol, penbutolol

Question 18

These drugs have both B blocking and vasodilator effects

Answer 18

Labetalol, carvedilol, and nebivolol

Question 19

Labetalol isomer that is a potent A blocker

Answer 19

SR

Question 20

Labetalol isomer that is a potent B blocker

Answer 20

RR

Question 21

Bp is lowered by this drug through reduction of vascular resitance(A blockade) without significant alteration in heart rate or CO

Answer 21

Labetalol

Question 22

Useful in treating hypertension of pheochromocytoma and hypertensive emergencies

Answer 22

Labetalol

Question 23

Isomer of carvedilol that is a nonselective B blocker

Answer 23

S-

Question 24

Both isomeres of this drug are potent A blockers

Answer 24

Carvedilol S- and R+

Question 25

B1 selective blocker with vasodilating properties not mediated by A receptor blockade

Answer 25

Nebivolol D- B1 L-vasodilation caused by release of NO via nitric oxide synthase

Question 26

B1 selective blocker that is rapidly metabolized by RBC esterases. Used in intraoperative and postoperative hypertension and sometimes for hypertensive emergencies particularly when hypertension is associated with tachycardia

Answer 26

Esmolol