Information flow through the cell (lecture 1) Flashcards
Mendel
1865 – Pea plants experiment
Darwin
1859 – Origin of species
Watson and Crick
1953
DNA ——> RNA
TRANSCRIPTION
RNA———> DNA
REVERSE TRANSCRIPTION
DNA ——–> DNA
REPLICATION
RNA ——–> PROTEIN
TRANSLATION
Eukaryotes
splicing to remove pre-mRNA
DNA—–> Pre mRNA——> mRNA
This added step increases the diversity of mRNA and proteins,
without increasing the number of genes
Ribosome
Produces polypeptide
Bacteria
DNA——> mRNA
Template
The sequence of RNA will be
identical to the DNA strand
NOT used as a template in
transcription.
Genetic Code
It is 64 codons, because there are four nucleotides
with an equal chance of being in any of the three
positions in a codon. 4x4x4 = 64
* Of the 64 triplets, 61 code for amino acids; 3 triplets
are “stop” signals to end translation
* The genetic code is redundant but not ambiguous;
no codon specifies more than one amino acid
* Codons must be read in the correct reading frame
(correct groupings) for the specified
polypeptide to be produced
Efficient Information Flow
DNA needs to simplify its structural complexity (quaternary to
primary), while proteins need to increase its complexity (primary to quaternary).
Evolution of the Genetic Code
- The genetic code is nearly universal, shared by the
simplest bacteria to the most complex animals - Genes can be transcribed and translated after being
transplanted from one species to another