Influenza Flashcards
1
Q
First Antiviral compound for Influenza
A
Adamantanes
2
Q
What are adamantanes used to treat
A
At low concentrations for treatment of Influenza A
3
Q
What do Adamantanes affect
A
Effects M2 ion channel formation, therefore H+ ions can in enter causing matrix layer to break down and release
4
Q
Are Adamantanes still approved by the FDA
A
No
5
Q
Two newer drugs for the treatment of Influenza
A
Relenza and Oseltamivir
6
Q
How is Relenza given
A
Aerosol
7
Q
How is Oseltamivir given
A
Tablet
8
Q
How do Relenza and Oseltamivir work
A
By mimicking Sialic Acid so that the NA active site is blocked and therefore SA can no longer be digested
9
Q
what virus is resistant to Relenza and Oseltamivir
A
H3N2 virus
