Herpes Flashcards
Is there a cure for Herpes Simplex virus 1 and 2
no, it lasts for lifetime
3 antivirals used to treat HSV 1+2
Acyclovir, Valacyclovir and Famcyclovir
What is Acyclovir used to treat?
Cold sores
What does Acyclovir inhibit?
Herpesvirus DNA polymerase
What is the difference between Acyclovir and Valacyclovir
Valacyclovir is an esterfied version of acyclovir, using esterases
What is famycyclovir a prodrug of
Penciclovir
What type of drug is now used instead of the three antivirals for HSV 1 and 2 due to growing drug resistance
Helicase primase inhibitors
Why are helicase primase inhibitors useful
they target three enzyme activities - DNA helicase, RNA polymerase and ssDNA stimulated ATPase
What drug is used to treat Herpes Zoster
Cidofovir derivatives
How many phosphorylation steps does Cidofovir need to become active
2
What are Bicyclic pyrimidine nucleoside analogues used to treat (BCNAs)
Herpes Zoster
What else might a person with Herpes Zoster need treatment for? And what is used to treat this
low mood and sleep, Tricyclic antidepressants
How do tricyclic antidepressants work?
They block serotonin and norepinephrine transporters = enhancement of extracellular concentrations of these neurotransmitters and therefore enhanced neurotransmission
Two drugs that target KSHV
Bevacizumab and Imatinib
What does Bevacizumab target and block
VEGF
