HIV and Hepatitis C Flashcards
What two drugs inhibit reverse transcriptase activity?
Non-nucleoside RT inhibitors (NNRTIs) and nucleoside analogue RT inhibitors (NRTIs)
Examples of NNRTIs
–VIR–
E.G EfaVIRenz, NeVIRapinem DelaVIRdine and EtraVIRdine
Example of NRTIs
Azidothymidine AZT
Two examples of protease inhibitors for HIV treatment
Saquinavir and Nelfinavir
What is combination treatment for HIV known as
HAART
What three parts of the HCV promoter is targeted
NS3, NS5A and NS5B
What is NS3 responsible for
Replication of the virus, protease and helicase (can unwind genomes).
What is NS5B responsible for
RNA-dependent RNA polymerase, makes an RNA compy of the RNA genome
what is NS5A responsible for
key target for antiviral therapy
What two 1st generation drugs inhibit NS3
Telaprevir and Boceprevir, have high resistance
What 2nd generation drug inhibits NS3
Simeprevir
Drugs that inhibit NS5B
Sofosbuvir
Two drugs inhibiting NS5A
Daclatasivir and Ledipasvir