HIV and Hepatitis C Flashcards

1
Q

What two drugs inhibit reverse transcriptase activity?

A

Non-nucleoside RT inhibitors (NNRTIs) and nucleoside analogue RT inhibitors (NRTIs)

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2
Q

Examples of NNRTIs

A

–VIR–

E.G EfaVIRenz, NeVIRapinem DelaVIRdine and EtraVIRdine

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3
Q

Example of NRTIs

A

Azidothymidine AZT

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4
Q

Two examples of protease inhibitors for HIV treatment

A

Saquinavir and Nelfinavir

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5
Q

What is combination treatment for HIV known as

A

HAART

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6
Q

What three parts of the HCV promoter is targeted

A

NS3, NS5A and NS5B

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7
Q

What is NS3 responsible for

A

Replication of the virus, protease and helicase (can unwind genomes).

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8
Q

What is NS5B responsible for

A

RNA-dependent RNA polymerase, makes an RNA compy of the RNA genome

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9
Q

what is NS5A responsible for

A

key target for antiviral therapy

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10
Q

What two 1st generation drugs inhibit NS3

A

Telaprevir and Boceprevir, have high resistance

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11
Q

What 2nd generation drug inhibits NS3

A

Simeprevir

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12
Q

Drugs that inhibit NS5B

A

Sofosbuvir

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13
Q

Two drugs inhibiting NS5A

A

Daclatasivir and Ledipasvir

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