Inflammatory response Flashcards
what are the 4 principles of the inflammatory response
initiation
amplification
termination
destruction
what is the response to injury or infection
chemical mediators and damaged tissues stimulate vasodilation
what does the stimulation of vasodilation lead to?
vascular changes - increasing blood vessel permeability to plasma.
what does increasing blood vessel permeability to plasma allow?
allows for clotting factors to move from bloodstream into surrounding tissue
what are released at the site of infection?
inflammatory mediators such as cytokines and chemokines
what is the rate of amplification dependant on?
the extent of the injury and the activation of mediators such as kinnins or complement
what are kinnins
they amplify the inflammatory response
what is complement
activation
role of intrinsic anti-inflammatory mechanisms
limit the tissue destruction and damage to normal cells
how does healing and repair happen?
reversing the vascular changes reducing further fluid and cellular access to injury site.
how is destruction in this pathway brought under control?
eliminating the damaged agents.
how are damaged agents eliminated?
phagocytosis - the process of engulfing and destroying unwanted or dangerous material.
what are the 4 stages of phagocytosis?
- oposins bound to microbes are recognized by cell surface receptors
- intracellular signalling results in enclosing microbe in phagysome
- lysosomes are released
- kill and degrade microbe
what is the role of a healthcare professional in the support and treatment of this
- wound assessment
- pain management
- recognition of signs and symptoms of further damage
- reduce swelling and promote healthy healing
