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Inflammatory Drugs Flashcards

1
Q

Methotrexate

A

DMARD

MOA- inhibits DHF reductase

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2
Q

Hydroxychloroquine

A

DMARD
MOA- stabilizes lysosomes and decreases chemotaxis
Side effects: Cinchinism and G6PD def. hemolysis

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3
Q

Sulfasalazine

A

DMARD

MOA- COX2 inhibitor

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4
Q

Corticosteroids

A

MOA- inhibits PLA2 to decrease LTs, IL-2, and PAF

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5
Q

Gold Salts

A

DMARD
MOA- decrease lysosomal and macrophage function
Side effects- bone marrow depression

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6
Q

D-Penicillamine

A

DMARD
MOA- suppress T cells and RF
Side effects- aplastic anemia and myesthenia gravis

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7
Q

Cyclophosphamide

A

DMARD
MOA- alkylating agent
Side effects- Hemorrhagic cystitis

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8
Q

Azathioprine

A

DMARD
MOA- inhibits purine synthesis (immunosuppressant)
Side effects- bone marrow suppression
Contraindication- Allopurinol (increases toxicity due to XO breaking down azathioprine)

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9
Q

Current RA Guidelines

A

1) Methotrexate
2) Hydroxychloroquine
3) Sulfasalazine

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10
Q

Infliximab

A

DMARD/Biologic
MOA- decreases TNF (monoclonal Ab)
Contraindications- other Biologics

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11
Q

Etanercept

A

DMARD/Biologic
MOA- Recominant TNF receptor that binds TNF
Side effect- Hypersensitivity, infection risk, pancytopenia, demyelination, SLE like syndrome

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12
Q

Leflunomide

A

DMARD
MOA- Pyrimidine synthesis inhibitor via Dihydro-orotic acid dehydrogenase inhibition
Side effects- alopecia, rash, hepatotoxicity

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13
Q

Anakinra

A

DMARD

MOA- IL-1 receptor antagonist

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14
Q

Adalimumab (Humira)

A

DMARD

MOA- Binds TNF (recombinant monoclonal Ab)

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15
Q

Abatacept

A

DMARD

MOA- Inhibits T cell activation via binding cell surface markers

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16
Q

Colchicine

A

Acute Gout treatment
MOA- binds tubulin decreasing LTB4 (leukocyte adhesion/migration)
Side effects- Acute- Diarrhea and GI pain Chronic- mylosuppression, peripheral neuropathy, hematuria, and alopecia

17
Q

Allopurinol

A

Chronic Gout treatment
MOA- XO inhibitor
Side effects- inhibits 6-mercaptopurine metabolism that can lead to liver toxicity

18
Q

Probenicid

A

Gout treatment
MOA- inhibits proximal tubule reabsorption of urate
Side effects- urate crystals in kidney due to increased excretion and inhibits secretion of acidic drugs (penicillins)

19
Q

Sulfinpyrazone

A

Gout treatment
MOA- inhibits proximal tubule reabsorption of urate (GFR dependent)
Side effects- GI distress, rash, nephrotic syndrome, and inhibits platelet aggregation

Pharm (4 decks)

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