Immunological Drugs Flashcards
Cyclosporine
Organ Transplant
MOA- binds to cyclophillin leading to calcineurin inhibition inhibiting TFs for IL-2, IL-3, and Interferon-gamma
Side effects- nephrotoxicity, gingival hyperplasia, hypertension
Toxicity- viral infections and lymphoma
Tacrolimus
Organ Transplant and used to treat atopic dermatitis and psoriasis
MOA- Calcineurin inhibitor of IL-2
Side effects- peripheral neuropathy, hypertension, pleural effusion, hyperglycemia, nephrotoxicity
Sirolimus (Rapamycin)
Organ Transplant
MOA- mTOR inhibitor that inhibits T cell proliferation
Side effects- Myelosuppression
Metabolized by cytochrome p450
Mycophenolate
Organ Transplant
MOA- inhibits purine synthesis
Side effects- hypertension, peripheral edema, GI distress
Thalidomide
Use- Cancer, TB, leprosy, erythema nodosum leprosum, cachexia
MOA- Inhibits IL-2, TNF, and angiogenesis cytokines
Side effects- Teratogenic (phocomelia)
Azathioprine
Organ Transplant
MOA- immunosuppression due to conversion to 6-mercaptopurine
Side effects- leukopenia, thrombocytopenia, hepatotoxicity
Contraindications- Allopurinol increases azathioprine effects
Muromonab-CD3 (OKT3)
Acute Renal Transplant and prevents cytokine release syndrome
MOA- CD3 antibody
IV Immune Globulin (IVIG)
Use- Congenital agammaglobinemia, autoimmune disease, Guillain-Barre Syndrome
Side effects- Hypersensitivity reactions (IgA is most common)
Interferon Alpha
Use- Hepatitis, Leukemia
Interferon Beta
Use- MS
Interferon Gamma
Chronic Granulomatous Disease
IL-11
Use- Thrombocytopenia
Thrombopoietin
Use- Thrombocytopenia
Erythropoietin
Use- Anemia
IL-2 (Aldesleukin)
Use- Renal cell carcinoma
