Inflammatory Bowel Disease Lecture Powerpoint

Question 1

Crohn’s disease description***

Answer 1

-Inflammation and ulceration (eventually fistula) somewhere along any point of the GI tract (but most often the terminal ileum and right colon) that involves the full thickness of the bowel in a patchy, non-continuous distribution (skip lesions), although the rectum is relativey spared. Chronic recurring condition marked by remissions and exacerbations

Question 2

Crohn’s disease etiology (3)**

Answer 2

• strong genetic component
• autoimmune response to evironmental factors/bacteria
• cigarette smoking increases susceptability in genetically susceptible

Question 3

Crohns disease typical presentation (6)

Answer 3

• female
• urban (processed food)
• teenage to young adulthood
• RLQ pain
• mass effect in the lower abdomen (firmness in intestine)
• high fever

Question 4

Bloody diarrhea should make you think of ____ and ___ as backup

Answer 4

ulcerative colitis, crohns

Question 5

Crohn’s disease often results in…

Answer 5

….fistulas (colo-bladder, colo-vaginal, etc.)

Question 6

Pyoderma gangrenosum

Answer 6

Cutaneous ulcerations caused by fistula tracts indicative of internal disease of the body

Question 7

Diagnostic test of choice for crohn’s disease and ulcerative colitis (3)

Answer 7

• colonscopy and biopsy (remember patchy lesions with healthy tissue between)
• EGD
• barium studies (string sign due to stricture of bowel wall)

Question 8

Lab studies for diagnosis of crohn’s disease (4)

Answer 8

• occult blood
• ova and parasite
• stool culture
• fecal lactoferrin***

Question 9

Tests to help differentiate between crohn’s and ulcerative colitis other than colonoscopy

Answer 9

-p-ANCA neg + ASCA = crohn’s

p-ANCA positive 40-80% of the time = UC

Question 10

Ulcerative colitis description

Answer 10

Chronic, recurrent condition marked by exacerbations and remissions where inflammation is localized primarily to the mucosa of the colon only and the rectum and is uniform and continuous with bloody diarrhea and tenesmus often as presenting symptoms

Question 11

Ulcerative colitis etiology (3)

Answer 11

• genetic predispostion
• cigarrette smoking is PROTECTIVE
• autoimmune

Question 12

Ulcerative colitis typical presentation (4)

Answer 12

• any age
• more common in industrialized urban areas (processed food)
• worsening bloody diarrhea
• bowel shortening on colonsocopy as well as continuous erythema only affecting the mucosa

Question 13

For quick immediate relief of IBD, use these drugs (2)

Answer 13

• prednisone/steroids (IV or PO)

- budenoside

Question 14

Untreated IBD increases risk for…

Answer 14

….colon cancer