Inflammation: Pathoma

Question 1

Acute Inflammation:

• Innate Response: PAMPS activate what? Located on? Then what is released? This is?
• Mast cells activated by? (3) Immediate response of mast cell? Delayed?
• Complement leads to?
• Classical pathway: C1 binds? Which is?
• Alternative pathway: Microbial products act directly on?
• C3A and C5A trigger what? C5A also chemotactic for? C5B acts as?
• Redness/warmth caused by? (3)
• Swelling caused by? (2)
• Pain? (2)
• Fever caused by macrophage release of? (2) Which do what? This leads to?

Answer 1

• TLR’s; APC’s; NF-KB; leads to all other mediators
• Trauma, C3A/C5A; cross linking IgE; Release histamine granules; Release Leukotrienes
• Swelling
• IgG or IgM (bound to antigen)
• Compliment
• Mast cell granulation; N’s; Opsonin
• Histamine, PG, Bradykinins
• Histamine; tissue damage
• Bradykinin, PGE2
• IL1, TNF; Increase COX activity at hypo; Increase PGE2

Question 2

Chronic Inflammation:

• Class 2: Marker? 2 hits?
• Class 1: Marker? 2 hits?
• Th1 release? (2) Effects?
• TH2 release? (3) Effects?
• B cell presents antigen to what? What then binds?
• Stem cells of bowel? Skin? Bone marrow?
• Labile tissue? Stable tissue? Permanent tissue?

Answer 2

• CD4+; Antigen/MHC, B7 on APC binds CD28
• CD8+; Antigen/MHC; IL2 from Th
• IL2 = Cyto t cell gf; INFgamma = attract macs
• IL4 = IgG and IgE class switching; IL5 = class switch to IgA and eisinophil chemo; IL10 supress TH1
• CD4+ helper; CD40
• Mucosal crypts; basel layer; hematopoietic
• Constantly regenerating, quiescent; no regeneration