Inflammation Key Facts Flashcards

1
Q

Causes of inflammation

A
Pathogens 
Allergens
Auto antigens 
Physical damage 
Extreme temperatures 
Non apoptotic cell death
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2
Q

Disease that result to inflammation

A
Infection 
Autoimmunity 
Hypersensitivity 
Trauma 
Fibrotic disease 
Cancer
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3
Q

Cells involved in inflammation

A
Neutrophills 
Macrophages 
Lymphocytes 
Eosinophills 
Mast cells
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4
Q

What are the four canonical features

A

Pain
Swelling
Hear
Redness

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5
Q

2 main vasodilators

A

Nitric acid

Histamine

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6
Q

Principle source of histamine

A

Mast cells
Basophills
Platelets

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7
Q

Action of histamine

A

Vasodilation
Increased vascular permeability
Endothelial activation

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8
Q

Principle source of prostaglandins

A

Mast cells leukocytes

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9
Q

Action of postaglandins

A

Vasodilation
Pain
Fever

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10
Q

What are some cytokines involved in inflammation

A

TNF, IL-1

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11
Q

Principle sources of cytokines

A

Macrophages, endothelial cells

Mast celks

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12
Q

Action of cytokines

A
Endothelial activation (adhesion molecules) 
Fever 
Malaise 
Pain 
Anorexia 
Shock
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13
Q

Chemokines source

A

Leukocytes

Activated macrophages

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14
Q

Action of chemokines

A

Chemotaxis, leukocyte activation

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15
Q

What is the complement associated with inflammation

A

C5a C3a C4a

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16
Q

Principal sources of complement

A

Plasma, produced in the liver

17
Q

Actions of complement

A

Leukocyte chemotaxis and activation
Vasodilation (mast cell stimulation)
Opsonisation

18
Q

What is the exudate

A

Fluid proteins and cells that have seeped out of the blood vessel

19
Q

What is an antigen 2

A

A molecular structure that can be recognised by an antibody

Any substance which the immune system can mount an antibofy or adaptive immune response

20
Q

What is an immunogen

A

Antigen independently capable of driving an immune response in absence of additional substances

21
Q

What is a hapten

A

A small molecule which does not alone act as an antigen but when bound to a larger molecule can create an antigen
Eg penicillin binding to a molecule which may cause theurapeutic processes

22
Q

Some diseases which are characterised by chronic inflammation

A
Arthiritis 
Asthma 
IBS 
Glumerulonephritis 
Hepatitis 
Psoriasis 
Multiple sclerosis 
Generally last a life time
23
Q

Some diseases associated with granulomatous?

A
TB 
Leprosy 
Foreign body granuloma 
Sarcoidosis 
Crohms disease
24
Q

What is granulomatous inflammation?

A

Chronic inflammation with distinct pattern of granuloma formation
Disruption of surrounding tissue with clear distinct scarring