Inflammation Key Facts Flashcards
Causes of inflammation
Pathogens Allergens Auto antigens Physical damage Extreme temperatures Non apoptotic cell death
Disease that result to inflammation
Infection Autoimmunity Hypersensitivity Trauma Fibrotic disease Cancer
Cells involved in inflammation
Neutrophills Macrophages Lymphocytes Eosinophills Mast cells
What are the four canonical features
Pain
Swelling
Hear
Redness
2 main vasodilators
Nitric acid
Histamine
Principle source of histamine
Mast cells
Basophills
Platelets
Action of histamine
Vasodilation
Increased vascular permeability
Endothelial activation
Principle source of prostaglandins
Mast cells leukocytes
Action of postaglandins
Vasodilation
Pain
Fever
What are some cytokines involved in inflammation
TNF, IL-1
Principle sources of cytokines
Macrophages, endothelial cells
Mast celks
Action of cytokines
Endothelial activation (adhesion molecules) Fever Malaise Pain Anorexia Shock
Chemokines source
Leukocytes
Activated macrophages
Action of chemokines
Chemotaxis, leukocyte activation
What is the complement associated with inflammation
C5a C3a C4a