Inflammation as a drug target Flashcards
What is ulcerative colitis?
Chronic hyper-inflammatory disease that affects the innermost lining of the colon and the rectum
What are the symptoms of Ulcerative colitis?
Fatigue Vomiting Weight loss Diarrhoea Abdominal pain
What can severe inflammation due to UC cause?
ulcers in the colon lining which can bleed and produce pus.
secondary infections can develop leading to sepsis.
What is Crohn’s disease?
Inflammation throughout the lining of the GI tract and gut.
What is IBD?
Inflammatory bowel disease
What causes IBD?
The immune system malfunctioning (attacking itself)
Genetics
What are the symptoms of IBD?
Fever Diarrhoea Fatigue Anaemia Abdominal pain
How are inflammatory disorders diagnosed?
Clinical diagnosis Antibody testing Inflammatory markers Imaging Tissue biopsy
Examples of imaging in inflammatory disorders diagnosis.
CT chest - Pulmonary fibrosis
Colonoscopy - Large intestine
Endoscopy - Small intestine
Examples of inflammatory markings in the diagnosis of inflammatory disorders?
CRP
Stool Sample
Blood tests
Complications of IBD? (systemic)
Osteoporosis
Joint Pain
Skin rashes
Local complications of IBD?
Anaemia
Bowel obstruction (which can lead to perforation + sepsis)
Increased risk of colon cancer
Malnutrition
What is a colostomy?
resecutive surgery of a section of the colon, separating the colon from the bowel.
A pouch can be placed across the stoma
What are corticosteroids, and why are they used to treat inflammatory conditions?
Steroid hormones produced in the adrenal cortex. They have metabolic functions and can aid inflammatory treatments.
ANTI-INFLAMMATORY PROPERTIES
The timeframe for inflammatory disorders:
Diagnosis
Treatment
Remission
Relapse//Flare (this leads back to treatment)
