Inflammation Flashcards
Inflammation is characterised by
Vasodilation Increased permeability of the capillaries Clotting of the fluid Migration of granulocytes and monocytes Swelling of tissue cells
First Line of Defence
Tissue macrophage
Second Line of Defence
Neutrophil Invasion
Third line of Defence
Second Macrophage Invasion
Fourth Line of Defence
Increased production of granulocytes and monocytes by the bone marrow
Inflamed tissue produces factors
IL-1
TNF
IL-1 and TNF cause the increased expression of which molecules?
Selectin
Intercellular Adhesion Molecules
Effect of Adhesion molecules on neutrophils
They bind to the complementary proteins on the neutrophils and cause margination
Effect of Adhesion molecules on the endothelium
The intercellular attachment loosen to cause diapered is
Macrophages produce substances in inflammation. Name these substances
IL-1 TNF GM-CSF G-CSF M-CSF
What is Pus
Dead macrophages and neutrophils, necrotic tissue and tissue fluid inside a cavity in the area of inflammation.