Erythropoiesis

Question 1

What is Diapedesis?

Answer 1

The passage of blood cells through the intact walls of the capillaries.

Question 2

Does a reticulocyte have a nucleus?

Answer 2

No, it doesn’t have a nucleus. It does have some basophilic substance with remnants of the Golgi apparatus, mitochondria, etc.

Question 3

What comes after Proerythroblast?

Answer 3

Basophilic Erythroblast

Question 4

What comes before Proerythroblast?

Answer 4

CFU-E stem cells which are committed stem cells

Question 5

What causes the formation of growth inducers and differentiation inducers?

Answer 5

Hypoxia in the case of RBCs

Any infection in the case of WBCs

Question 6

What does Tissue hypoxia lead to the production of?

Answer 6

Hypoxia-Inducible Factor-1 (HIF-1)

Question 7

Function of HIF-1

Answer 7

Activates the erythropoietin gene.

Question 8

Functions of Erythropoietin

Answer 8

Stimulates the production of proerythroblasts.

Speed up the process of erythropoiesis.

Question 9

Extramedullary hematopoiesis

Answer 9

Hematopoiesis occurring outside of the medulla of the bone (bone marrow). It occurs in fetal life.

Question 10

Vitamin B12 and folic acid are necessary for?

Answer 10

DNA synthesis

Question 11

The other name of folic acid is?

Answer 11

Pteroylglutamic acid

Question 12

Where is iron stored in our bodies?

Answer 12

Reticuloendothelial cells in the liver parenchyma in the form of ferritin.

Question 13

Fe2+ combines with apoferritin to form?

Answer 13

Ferritin

Question 14

What is Transferrin?

Answer 14

Fe2+ combined with the protein apotransferrin is called Transferrin.

Question 15

Journey of Transferrin

Answer 15

Transferrin goes to the bone marrow and it binds to the cell membrane of the erythroblast and taken in by endocytosis.

Question 16

Hemosiderin

Answer 16

When a group of ferritin molecules with low iron accumulates, it is called hemosiderin.